TY - JOUR
T1 - Sorting of β1-adrenergic receptors is mediated by pathways that are either dependent on or independent of type i PDZ, protein kinase A (PKA), and SAP97
AU - Nooh, Mohammed M.
AU - Chumpia, Maryanne M.
AU - Hamilton, Thomas B.
AU - Bahouth, Suleiman W.
PY - 2014/1/24
Y1 - 2014/1/24
N2 - Background: β1-AR trafficking is regulated by its PDZ that binds to a complex composed of SAP97, AKAP79, and PKA. Results: Type I PDZ-mediated recycling of the β1-AR was dependent on PKA-mediated phosphorylation of Ser312, whereas trafficking by non-PDZs was PKA-independent. Conclusion: Divergent trafficking pathways were involved in β1-AR recycling by type I PDZs versus non-PDZs. Significance: These results provide a roadmap for GPCR trafficking pathways.
AB - Background: β1-AR trafficking is regulated by its PDZ that binds to a complex composed of SAP97, AKAP79, and PKA. Results: Type I PDZ-mediated recycling of the β1-AR was dependent on PKA-mediated phosphorylation of Ser312, whereas trafficking by non-PDZs was PKA-independent. Conclusion: Divergent trafficking pathways were involved in β1-AR recycling by type I PDZs versus non-PDZs. Significance: These results provide a roadmap for GPCR trafficking pathways.
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U2 - 10.1074/jbc.M113.513481
DO - 10.1074/jbc.M113.513481
M3 - Article
C2 - 24324269
AN - SCOPUS:84893150401
SN - 0021-9258
VL - 289
SP - 2277
EP - 2294
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 4
ER -