Somatostatin imaging of neuroendocrine-differentiated prostate cancer

Thomas A. Hope, Rahul Aggarwal, Jeff P. Simko, Henry F. Vanbrocklin, Charles J. Ryan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

After prolonged androgen deprivation therapy, a subset of castrate-resistant prostate cancer patients will develop neuroendocrine prostate cancer (NEPC) associated with resistance to further hormonal therapy and frequent visceral metastases. Imaging the presence of somatostatin receptors on the cancer cell surface may provide a readily available, noninvasive means to distinguish adenocarcinoma from NEPC. This distinction is important for therapeutic decision making and may open the door for developing novel radionuclide targets for the treatment of this aggressive subtype of prostate cancer. We describe a case of NEPC successfully imaged using 111In-labeled octreotide.

Original languageEnglish (US)
Pages (from-to)540-541
Number of pages2
JournalClinical Nuclear Medicine
Volume40
Issue number6
DOIs
StatePublished - Jun 25 2015

Keywords

  • FDG
  • neuroendocrine
  • octreotide
  • prostate cancer
  • somatostatin

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