Solvent-free solid acid-catalyzed electrophilic annelations: A new green approach for the synthesis of substituted five-membered N-heterocycles

Mohammed Abid, Andrew Spaeth, Béla Török

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

An effective microwave-induced, solid acid-catalyzed, environmentally benign synthesis of substituted pyrroles, indoles and carbazoles under solvent-free conditions is described. The new synthetic methodology is based on the use of a considerably strong solid acid, K-10 montmorillonite. Both the cyclialkylation of amines and annelation of pyrroles and indoles have been completed within minutes and provided excellent (75-98%) yields with practically 100% selectivity.

Original languageEnglish (US)
Pages (from-to)2191-2196
Number of pages6
JournalAdvanced Synthesis and Catalysis
Volume348
Issue number15
DOIs
StatePublished - Oct 1 2006

Keywords

  • Carbazoles
  • Indoles
  • K-10 montmorillonite
  • Microwave heating
  • Pyrroles
  • Solid acids

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