Solution-phase synthesis of chiral O-acyl isodipeptides

Mirna El Khatib; Lilibeth Jauregui; Srinivasa R. Tala; Levan Khelashvili; Alan R. Katritzky

doi:10.1039/c1md00130b

Solution-phase synthesis of chiral O-acyl isodipeptides

Mirna El Khatib, Lilibeth Jauregui, Srinivasa R. Tala, Levan Khelashvili, Alan R. Katritzky

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

O-Acylation of N-Boc-protected-serine and -threonine with N-Pg-(α-aminoacyl)benzotriazoles afforded the chiral O-acylated isodipeptides at 23 °C in yields of 74-91%.

Original language	English (US)
Pages (from-to)	1087-1092
Number of pages	6
Journal	MedChemComm
Volume	2
Issue number	11
DOIs	https://doi.org/10.1039/c1md00130b
State	Published - Nov 2011

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title = "Solution-phase synthesis of chiral O-acyl isodipeptides",

abstract = "O-Acylation of N-Boc-protected-serine and -threonine with N-Pg-(α-aminoacyl)benzotriazoles afforded the chiral O-acylated isodipeptides at 23 °C in yields of 74-91%.",

author = "{El Khatib}, Mirna and Lilibeth Jauregui and Tala, {Srinivasa R.} and Levan Khelashvili and Katritzky, {Alan R.}",

year = "2011",

month = nov,

doi = "10.1039/c1md00130b",

language = "English (US)",

volume = "2",

pages = "1087--1092",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "11",

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TY - JOUR

T1 - Solution-phase synthesis of chiral O-acyl isodipeptides

AU - El Khatib, Mirna

AU - Jauregui, Lilibeth

AU - Tala, Srinivasa R.

AU - Khelashvili, Levan

AU - Katritzky, Alan R.

PY - 2011/11

Y1 - 2011/11

N2 - O-Acylation of N-Boc-protected-serine and -threonine with N-Pg-(α-aminoacyl)benzotriazoles afforded the chiral O-acylated isodipeptides at 23 °C in yields of 74-91%.

AB - O-Acylation of N-Boc-protected-serine and -threonine with N-Pg-(α-aminoacyl)benzotriazoles afforded the chiral O-acylated isodipeptides at 23 °C in yields of 74-91%.

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U2 - 10.1039/c1md00130b

DO - 10.1039/c1md00130b

M3 - Article

AN - SCOPUS:80455163185

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VL - 2

SP - 1087

EP - 1092

JO - MedChemComm

JF - MedChemComm

IS - 11

ER -

Solution-phase synthesis of chiral O-acyl isodipeptides

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