@article{c03972c9bd6f45048b5d9d4abb91c028,
title = "Solution NMR structures of pyrenophora tritici-repentis toxb and its inactive homolog reveal potential determinants of toxin activity",
abstract = "Background: ToxB is a proteinaceous toxin but its homolog toxb has no toxic activity.Results: Both adopt a β-sandwich fold stabilized by two disulfide bonds but differ in the dynamics of one sandwich half.Conclusion: Toxicity is correlated with decreased compactness, increased flexibility, and polymorphism in an active site loop.Significance: ToxB activity depends on interplay between internal dynamics and interactions with putative targets.",
author = "Afua Nyarko and Singarapu, {Kiran K.} and Melania Figueroa and Manning, {Viola A.} and Iovanna Pandelova and Wolpert, {Thomas J.} and Ciuffetti, {Lynda M.} and Elisar Barbar",
note = "Publisher Copyright: {\textcopyright} 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",
year = "2014",
month = sep,
day = "12",
doi = "10.1074/jbc.M114.569103",
language = "English (US)",
volume = "289",
pages = "25946--25956",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "37",
}