Soluble combinatorial libraries of organic, peptidomimetic and peptide diversities

S. E. Blondelle; E. Pérez-Payá; C. T. Dooley; C. Pinilla; R. A. Houghten

doi:10.1016/0165-9936(95)91476-9

Soluble combinatorial libraries of organic, peptidomimetic and peptide diversities

S. E. Blondelle, E. Pérez-Payá, C. T. Dooley, C. Pinilla, R. A. Houghten

Research output: Contribution to journal › Article › peer-review

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Abstract

Molecular diversity provides a source of novel lead compounds for drug discovery. In particular, soluble combinatorial libraries composed of millions of peptides, peptidomimetics and organic compounds have lead to the successful identification of new pharmacophores. The current development of structurally defined combinatorial libraries will broaden the applicability of combinatorial chemistry.

Original language	English (US)
Pages (from-to)	83-92
Number of pages	10
Journal	TrAC - Trends in Analytical Chemistry
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/0165-9936(95)91476-9
State	Published - Feb 1995
Externally published	Yes

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abstract = "Molecular diversity provides a source of novel lead compounds for drug discovery. In particular, soluble combinatorial libraries composed of millions of peptides, peptidomimetics and organic compounds have lead to the successful identification of new pharmacophores. The current development of structurally defined combinatorial libraries will broaden the applicability of combinatorial chemistry.",

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AU - Dooley, C. T.

AU - Pinilla, C.

AU - Houghten, R. A.

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AB - Molecular diversity provides a source of novel lead compounds for drug discovery. In particular, soluble combinatorial libraries composed of millions of peptides, peptidomimetics and organic compounds have lead to the successful identification of new pharmacophores. The current development of structurally defined combinatorial libraries will broaden the applicability of combinatorial chemistry.

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Soluble combinatorial libraries of organic, peptidomimetic and peptide diversities

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