Solubilized phenyl-pyrazole ureas as potent, selective 5-HT2A inverse-agonists and their application as antiplatelet agents

Peter I. Dosa; Sonja Strah-Pleynet; Honnappa Jayakumar; Martin Casper; Marc Decaire; Yifeng Xiong; Juerg Lehmann; Karoline Choi; Katie Elwell; Amy Wong; Robert R. Webb; John W. Adams; Juan Ramirez; Jeremy G. Richman; William Thomsen; Graeme Semple; Bradley R. Teegarden

doi:10.1016/j.bmcl.2009.07.073

Solubilized phenyl-pyrazole ureas as potent, selective 5-HT_2A inverse-agonists and their application as antiplatelet agents

Peter I. Dosa, Sonja Strah-Pleynet, Honnappa Jayakumar, Martin Casper, Marc Decaire, Yifeng Xiong, Juerg Lehmann, Karoline Choi, Katie Elwell, Amy Wong, Robert R. Webb, John W. Adams, Juan Ramirez, Jeremy G. Richman, William Thomsen, Graeme Semple, Bradley R. Teegarden

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Potent 5-HT_2A inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective compounds that proved effective in modulating 5HT-induced amplification of ADP-stimulated human platelet aggregation.

Original language	English (US)
Pages (from-to)	5486-5489
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2009.07.073
State	Published - Sep 15 2009
Externally published	Yes

Keywords

5-HT
Antiplatelet
Antithrombosis

Publisher link

10.1016/j.bmcl.2009.07.073

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Dosa, P. I., Strah-Pleynet, S., Jayakumar, H., Casper, M., Decaire, M., Xiong, Y., Lehmann, J., Choi, K., Elwell, K., Wong, A., Webb, R. R., Adams, J. W., Ramirez, J., Richman, J. G., Thomsen, W., Semple, G., & Teegarden, B. R. (2009). Solubilized phenyl-pyrazole ureas as potent, selective 5-HT_2A inverse-agonists and their application as antiplatelet agents. Bioorganic and Medicinal Chemistry Letters, 19(18), 5486-5489. https://doi.org/10.1016/j.bmcl.2009.07.073

Dosa, PI, Strah-Pleynet, S, Jayakumar, H, Casper, M, Decaire, M, Xiong, Y, Lehmann, J, Choi, K, Elwell, K, Wong, A, Webb, RR, Adams, JW, Ramirez, J, Richman, JG, Thomsen, W, Semple, G & Teegarden, BR 2009, 'Solubilized phenyl-pyrazole ureas as potent, selective 5-HT_2A inverse-agonists and their application as antiplatelet agents', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 18, pp. 5486-5489. https://doi.org/10.1016/j.bmcl.2009.07.073

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abstract = "Potent 5-HT2A inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective compounds that proved effective in modulating 5HT-induced amplification of ADP-stimulated human platelet aggregation.",

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AU - Strah-Pleynet, Sonja

AU - Jayakumar, Honnappa

AU - Casper, Martin

AU - Decaire, Marc

AU - Xiong, Yifeng

AU - Lehmann, Juerg

AU - Choi, Karoline

AU - Elwell, Katie

AU - Wong, Amy

AU - Webb, Robert R.

AU - Adams, John W.

AU - Ramirez, Juan

AU - Richman, Jeremy G.

AU - Thomsen, William

AU - Semple, Graeme

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