Solphenazines A-F, glycosylated phenazines from Streptomyces sp. strain DL-93

Yudi Rusman, Lisa M. Oppegard, Hiroshi Hiasa, Christopher Gelbmann, Christine Salomon

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

During a survey of actinobacteria known to suppress the growth of Streptomyces scabies (the causative agent of potato scab disease) in vivo, six new rhamnosylated alkaloids, the solphenazines A-F (1-6), were isolated from a biological control strain of Streptomyces (DL-93). The known rhamnosyl analogue of paraben (9) was also isolated along with a new rhamnosylated derivative of N-methyl-p-aminobenzoic acid (10). None of the compounds exhibited any antibacterial or antifungal activity against a standard panel of microorganisms, but compounds 1, 2, and 6 displayed some cytotoxicity against HCT-116 cancer cells. Additional in vitro testing provided data suggesting that the cytotoxic activity is not due to DNA intercalation or topoisomerase inhibition.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalJournal of Natural Products
Volume76
Issue number1
DOIs
StatePublished - Jan 25 2013

Fingerprint Dive into the research topics of 'Solphenazines A-F, glycosylated phenazines from Streptomyces sp. strain DL-93'. Together they form a unique fingerprint.

Cite this