TY - JOUR
T1 - Solid‐phase peptide synthesis
T2 - a silver anniversary report
AU - Barany, George
AU - KNEIB‐CORDONIER, NANCY
AU - MULLEN, DANIEL G.
PY - 1987/12
Y1 - 1987/12
N2 - It has been a quarter of a century since Merrifield's initial report on solid‐phase peptide synthesis. The field has matured significantly in recent years with a better understanding of the underlying chemistry. This is reflected by new, milder orthogonal protection schemes and more efficient coupling methods, some of which have been incorporated into automated systems. Advances in purification, especially high performance liquid chromatography, have had a major impact. The efficacy of these improvements has been demonstrated by an impressive litany of applications to biological problems.
AB - It has been a quarter of a century since Merrifield's initial report on solid‐phase peptide synthesis. The field has matured significantly in recent years with a better understanding of the underlying chemistry. This is reflected by new, milder orthogonal protection schemes and more efficient coupling methods, some of which have been incorporated into automated systems. Advances in purification, especially high performance liquid chromatography, have had a major impact. The efficacy of these improvements has been demonstrated by an impressive litany of applications to biological problems.
KW - anchoring handles
KW - biologically active peptides
KW - high performance liquid chromatography
KW - orthogonal protection schemes
KW - solid‐phase peptide synthesis
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U2 - 10.1111/j.1399-3011.1987.tb03385.x
DO - 10.1111/j.1399-3011.1987.tb03385.x
M3 - Review article
C2 - 3326854
AN - SCOPUS:0023493072
SN - 0367-8377
VL - 30
SP - 705
EP - 739
JO - International Journal of Peptide and Protein Research
JF - International Journal of Peptide and Protein Research
IS - 6
ER -