Solid‐phase peptide synthesis: a silver anniversary report

George Barany, NANCY KNEIB‐CORDONIER, DANIEL G. MULLEN

Research output: Contribution to journalReview articlepeer-review

153 Scopus citations

Abstract

It has been a quarter of a century since Merrifield's initial report on solid‐phase peptide synthesis. The field has matured significantly in recent years with a better understanding of the underlying chemistry. This is reflected by new, milder orthogonal protection schemes and more efficient coupling methods, some of which have been incorporated into automated systems. Advances in purification, especially high performance liquid chromatography, have had a major impact. The efficacy of these improvements has been demonstrated by an impressive litany of applications to biological problems.

Original languageEnglish (US)
Pages (from-to)705-739
Number of pages35
JournalInternational Journal of Peptide and Protein Research
Volume30
Issue number6
DOIs
StatePublished - Dec 1987

Keywords

  • anchoring handles
  • biologically active peptides
  • high performance liquid chromatography
  • orthogonal protection schemes
  • solid‐phase peptide synthesis

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