TY - JOUR
T1 - Solid-state properties and crystallization behavior of PHA-739521 polymorphs
AU - Sun, Changquan (Calvin)
PY - 2006/8/17
Y1 - 2006/8/17
N2 - PHA-739521 is an experimental compound that exhibits polymorphism. The two anhydrous crystal forms, I and II, are characterized using powder X-ray diffractometry, thermal analyses, moisture sorption gravimetry. Both Forms I and II are non-hygroscopic and are stable to compaction pressure. The melting temperature is about 152 °C for Form I and 168 °C for Form II. Forms I and II are enantiotropically related where Form I is more stable below a transition temperature of approximately 70 °C. Crystallization behavior of this compound from solutions and during heating is also studied. Information obtained is used to design an appropriate crystallization process to successfully manufacture desired polymorph at large scale.
AB - PHA-739521 is an experimental compound that exhibits polymorphism. The two anhydrous crystal forms, I and II, are characterized using powder X-ray diffractometry, thermal analyses, moisture sorption gravimetry. Both Forms I and II are non-hygroscopic and are stable to compaction pressure. The melting temperature is about 152 °C for Form I and 168 °C for Form II. Forms I and II are enantiotropically related where Form I is more stable below a transition temperature of approximately 70 °C. Crystallization behavior of this compound from solutions and during heating is also studied. Information obtained is used to design an appropriate crystallization process to successfully manufacture desired polymorph at large scale.
KW - Crystals
KW - PHA-739521
KW - Physical characterization
KW - Polymorph
KW - Solid state
KW - Thermal analysis
KW - Transition temperature
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U2 - 10.1016/j.ijpharm.2006.03.044
DO - 10.1016/j.ijpharm.2006.03.044
M3 - Article
C2 - 16720086
AN - SCOPUS:33745895267
SN - 0378-5173
VL - 319
SP - 114
EP - 120
JO - International journal of pharmaceutics
JF - International journal of pharmaceutics
IS - 1-2
ER -