Abstract
Solid-phase synthesis has been applied successfully for the preparation of peptides, small proteins, oligonucleotides, and small organic molecules. A crucial part of the overall synthesis plan is the choice of an appropriate "handle" (linker) for attachment to the support. Here we describe a novel and general concept for solid-phase synthesis that involves attachment of a backbone amide nitrogen to an appropriate handle. This backbone amide linker (BAL) approach allows for the preparation of C-terminal-modified and cyclic peptides, small organic molecules, and modified amino sugars, as well as combinatorial synthesis applications.
Original language | English (US) |
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Pages (from-to) | 2787-2795 |
Number of pages | 9 |
Journal | Chemistry - A European Journal |
Volume | 5 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1999 |
Keywords
- Carbohydrates
- Combinatorial chemistry
- Handles
- Libraries
- Linkers
- Peptides
- Solid-phase synthesis