Solid-phase synthesis of diketopiperazines, useful scaffolds for combinatorial chemistry

Montserrat Del Fresno, Jordi Alsina, Miriam Royo, George Barany, Fernando Albericio

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Diketopiperazines, which are cyclic dipeptides, are often formed by a side reaction of solid-phase peptide synthesis. Using the new 'Backbone Amide Linker,' this chemistry can be conveniently harnessed for the intentional preparation of diketopiperazines. These products will be useful scaffolds for combinatorial chemistry, since they incorporate three different points of diversity: both amine acid side-chains and one (of the two) amide bonds.

Original languageEnglish (US)
Pages (from-to)2639-2642
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number17
DOIs
StatePublished - Apr 23 1998

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