Solid-phase synthesis of C-terminal peptide aldehydes from amino acetals anchored to a backbone amide linker (BAL) handle

Fanny Guillaumie; Joseph C. Kappel; Nicholas M. Kelly; George Barany; Knud J. Jensen

doi:10.1016/S0040-4039(00)00950-3

Solid-phase synthesis of C-terminal peptide aldehydes from amino acetals anchored to a backbone amide linker (BAL) handle

Fanny Guillaumie, Joseph C. Kappel, Nicholas M. Kelly, George Barany, Knud J. Jensen

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Peptide aldehydes were synthesized, starting from amino acetals, by a Solid-phase backbone amide linker (BAL) strategy.

Original language	English (US)
Pages (from-to)	6131-6135
Number of pages	5
Journal	Tetrahedron Letters
Volume	41
Issue number	32
DOIs	https://doi.org/10.1016/S0040-4039(00)00950-3
State	Published - Aug 5 2000

Bibliographical note

Funding Information:
We are grateful to Annette Nordestgaard from Phytera Symbion for LC/MS analyses, and Professor Fernando Albericio for valuable discussions. We thank the Leo Foundation (K.J.), the Lundbeck Foundation (K.J.), and the NIH (GM 42722 to GB) for financial support. J.K. was supported by an NIH Biotechnology Training Grant (GM 08347).

Keywords

Amino acetals
BAL
Peptide aldehydes
Solid-phase synthesis

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10.1016/S0040-4039(00)00950-3

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title = "Solid-phase synthesis of C-terminal peptide aldehydes from amino acetals anchored to a backbone amide linker (BAL) handle",

abstract = "Peptide aldehydes were synthesized, starting from amino acetals, by a Solid-phase backbone amide linker (BAL) strategy.",

keywords = "Amino acetals, BAL, Peptide aldehydes, Solid-phase synthesis",

author = "Fanny Guillaumie and Kappel, {Joseph C.} and Kelly, {Nicholas M.} and George Barany and Jensen, {Knud J.}",

note = "Funding Information: We are grateful to Annette Nordestgaard from Phytera Symbion for LC/MS analyses, and Professor Fernando Albericio for valuable discussions. We thank the Leo Foundation (K.J.), the Lundbeck Foundation (K.J.), and the NIH (GM 42722 to GB) for financial support. J.K. was supported by an NIH Biotechnology Training Grant (GM 08347).",

year = "2000",

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doi = "10.1016/S0040-4039(00)00950-3",

language = "English (US)",

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T1 - Solid-phase synthesis of C-terminal peptide aldehydes from amino acetals anchored to a backbone amide linker (BAL) handle

AU - Guillaumie, Fanny

AU - Kappel, Joseph C.

AU - Kelly, Nicholas M.

AU - Barany, George

AU - Jensen, Knud J.

N1 - Funding Information: We are grateful to Annette Nordestgaard from Phytera Symbion for LC/MS analyses, and Professor Fernando Albericio for valuable discussions. We thank the Leo Foundation (K.J.), the Lundbeck Foundation (K.J.), and the NIH (GM 42722 to GB) for financial support. J.K. was supported by an NIH Biotechnology Training Grant (GM 08347).

PY - 2000/8/5

Y1 - 2000/8/5

N2 - Peptide aldehydes were synthesized, starting from amino acetals, by a Solid-phase backbone amide linker (BAL) strategy.

AB - Peptide aldehydes were synthesized, starting from amino acetals, by a Solid-phase backbone amide linker (BAL) strategy.

KW - Amino acetals

KW - BAL

KW - Peptide aldehydes

KW - Solid-phase synthesis

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U2 - 10.1016/S0040-4039(00)00950-3

DO - 10.1016/S0040-4039(00)00950-3

M3 - Article

AN - SCOPUS:0034609142

SN - 0040-4039

VL - 41

SP - 6131

EP - 6135

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 32

ER -

Solid-phase synthesis of C-terminal peptide aldehydes from amino acetals anchored to a backbone amide linker (BAL) handle

Abstract

Bibliographical note

Keywords

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