Solid-phase synthesis of branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones

Adel Nefzi, Marc A. Giulianotti, Richard A. Houghten

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

An efficient solid-phase synthesis method is described for branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones using 4-fluoro-3-nitrobenzoic acid. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)2283-2287
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number14
DOIs
StatePublished - Apr 1 2000
Externally publishedYes

Bibliographical note

Funding Information:
We thank Eileen Weiler for editorial assistance. This work was funded by the National Cancer Institute Grant No. CA78040 (Houghten).

Keywords

  • Benzimidazolinethiones
  • Solid-phase synthesis
  • Tetrahydroquinoxalinediones
  • Thiohydantoin

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