Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides

Adel Nefzi; Marc A. Giulianotti; Nhi A. Ong; Richard A. Houghten

doi:10.1021/ol000225e

Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides

Adel Nefzi
, Marc A. Giulianotti
, Nhi A. Ong
, Richard A. Houghten

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

(matrix presented) The exhaustive reduction of resin-bound tripeptides with borane afforded three secondary amines and one primary amine. The treatment of the solid-support polyamines with thiocarbonyldiimidazole afforded, following cleavage of the solid support, the corresponding bis-cyclic thiourea in good purity and yield.

Original language	English (US)
Pages (from-to)	3349-3350
Number of pages	2
Journal	Organic Letters
Volume	2
Issue number	21
DOIs	https://doi.org/10.1021/ol000225e
State	Published - Oct 19 2000
Externally published	Yes

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@article{06282be8fa14402bb32275a2f970c6c1,

title = "Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides",

abstract = "(matrix presented) The exhaustive reduction of resin-bound tripeptides with borane afforded three secondary amines and one primary amine. The treatment of the solid-support polyamines with thiocarbonyldiimidazole afforded, following cleavage of the solid support, the corresponding bis-cyclic thiourea in good purity and yield.",

author = "Adel Nefzi and Giulianotti, \{Marc A.\} and Ong, \{Nhi A.\} and Houghten, \{Richard A.\}",

year = "2000",

month = oct,

day = "19",

doi = "10.1021/ol000225e",

language = "English (US)",

volume = "2",

pages = "3349--3350",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "21",

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TY - JOUR

T1 - Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides

AU - Nefzi, Adel

AU - Giulianotti, Marc A.

AU - Ong, Nhi A.

AU - Houghten, Richard A.

PY - 2000/10/19

Y1 - 2000/10/19

N2 - (matrix presented) The exhaustive reduction of resin-bound tripeptides with borane afforded three secondary amines and one primary amine. The treatment of the solid-support polyamines with thiocarbonyldiimidazole afforded, following cleavage of the solid support, the corresponding bis-cyclic thiourea in good purity and yield.

AB - (matrix presented) The exhaustive reduction of resin-bound tripeptides with borane afforded three secondary amines and one primary amine. The treatment of the solid-support polyamines with thiocarbonyldiimidazole afforded, following cleavage of the solid support, the corresponding bis-cyclic thiourea in good purity and yield.

UR - https://www.scopus.com/pages/publications/0034687176

UR - https://www.scopus.com/pages/publications/0034687176#tab=citedBy

U2 - 10.1021/ol000225e

DO - 10.1021/ol000225e

M3 - Article

C2 - 11029207

AN - SCOPUS:0034687176

SN - 1523-7060

VL - 2

SP - 3349

EP - 3350

JO - Organic Letters

JF - Organic Letters

IS - 21

ER -

Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides

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