Abstract
A new method for the solid phase synthesis of benzothiazoles and 2-arylamino-3-carboxyl-4-hydroxy-5-arylthiophenes is described. Resin bound cyclic malonic acid ester was reacted with aryl isothiocyanates and then with bromine or α-bromoketones, followed by treatment with perchloric acid or sodium methoxide to afford substituted 2-methylbenzothiazoles or 2-arylamino-3-carboxyl-4-hydroxy-5-arylthiophenes, respectively, in high yields and purities.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4851-4856 |
| Number of pages | 6 |
| Journal | Tetrahedron |
| Volume | 59 |
| Issue number | 26 |
| DOIs | |
| State | Published - Jun 23 2003 |
| Externally published | Yes |
Bibliographical note
Funding Information:We are grateful to the Natural Science Foundation of China (Project No.20072032).
Keywords
- Benzothiazole
- Cyclic malonic acid ester
- Resin-bound
- Thiophene
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