Solid phase synthesis of benzothiazole and thiophene derivatives based on resin-bound cyclic malonic acid ester

Xian Huang, Jing Tang

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A new method for the solid phase synthesis of benzothiazoles and 2-arylamino-3-carboxyl-4-hydroxy-5-arylthiophenes is described. Resin bound cyclic malonic acid ester was reacted with aryl isothiocyanates and then with bromine or α-bromoketones, followed by treatment with perchloric acid or sodium methoxide to afford substituted 2-methylbenzothiazoles or 2-arylamino-3-carboxyl-4-hydroxy-5-arylthiophenes, respectively, in high yields and purities.

Original languageEnglish (US)
Pages (from-to)4851-4856
Number of pages6
JournalTetrahedron
Volume59
Issue number26
DOIs
StatePublished - Jun 23 2003

Keywords

  • Benzothiazole
  • Cyclic malonic acid ester
  • Resin-bound
  • Thiophene

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