Solid-phase synthesis of 2,3,5,6-tetrahydro-1H-imidazo[1,2-a]benzo[d]- [1,3]diazepines via Pd(OAc)2/Cu(OAc)2-cocatalyzed cyclization

Lili Ou; Zhanying Shao; Wenteng Chen; Marc A. Giulianotti; Richard A. Houghten; Yongping Yu

doi:10.1055/s-0030-1261186

Solid-phase synthesis of 2,3,5,6-tetrahydro-1H-imidazo[1,2-a]benzo[d]- [1,3]diazepines via Pd(OAc)₂/Cu(OAc)₂-cocatalyzed cyclization

Lili Ou, Zhanying Shao, Wenteng Chen, Marc A. Giulianotti, Richard A. Houghten, Yongping Yu

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

An efficient approach for the solid-phase synthesis of 2,3,5,6-tetrahydro- 1H-imidazo[1,2-a]benzo[d][1,3]diazepines has been developed. It was realized by Pd(OAc)₂/Cu(OAc)₂-cocatalyzed intramolecular aryl guanidinylation.

Original language	English (US)
Article number	W11911ST
Pages (from-to)	2259-2261
Number of pages	3
Journal	Synlett
Issue number	15
DOIs	https://doi.org/10.1055/s-0030-1261186
State	Published - 2011
Externally published	Yes

Keywords

1,3-benzodiazepines
Pd(OAc)/Cu(OAc)
cyclization
guanidinylation
solid-phase synthesis

Publisher link

10.1055/s-0030-1261186

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Cite this

@article{d55f72d5c38a4cd1a2fbeab8696377bd,

title = "Solid-phase synthesis of 2,3,5,6-tetrahydro-1H-imidazo[1,2-a]benzo[d]- [1,3]diazepines via Pd(OAc)2/Cu(OAc)2-cocatalyzed cyclization",

abstract = "An efficient approach for the solid-phase synthesis of 2,3,5,6-tetrahydro- 1H-imidazo[1,2-a]benzo[d][1,3]diazepines has been developed. It was realized by Pd(OAc)2/Cu(OAc)2-cocatalyzed intramolecular aryl guanidinylation.",

keywords = "1,3-benzodiazepines, Pd(OAc)/Cu(OAc), cyclization, guanidinylation, solid-phase synthesis",

author = "Lili Ou and Zhanying Shao and Wenteng Chen and Giulianotti, {Marc A.} and Houghten, {Richard A.} and Yongping Yu",

year = "2011",

doi = "10.1055/s-0030-1261186",

language = "English (US)",

pages = "2259--2261",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "15",

}

TY - JOUR

T1 - Solid-phase synthesis of 2,3,5,6-tetrahydro-1H-imidazo[1,2-a]benzo[d]- [1,3]diazepines via Pd(OAc)2/Cu(OAc)2-cocatalyzed cyclization

AU - Ou, Lili

AU - Shao, Zhanying

AU - Chen, Wenteng

AU - Giulianotti, Marc A.

AU - Houghten, Richard A.

AU - Yu, Yongping

PY - 2011

Y1 - 2011

N2 - An efficient approach for the solid-phase synthesis of 2,3,5,6-tetrahydro- 1H-imidazo[1,2-a]benzo[d][1,3]diazepines has been developed. It was realized by Pd(OAc)2/Cu(OAc)2-cocatalyzed intramolecular aryl guanidinylation.

AB - An efficient approach for the solid-phase synthesis of 2,3,5,6-tetrahydro- 1H-imidazo[1,2-a]benzo[d][1,3]diazepines has been developed. It was realized by Pd(OAc)2/Cu(OAc)2-cocatalyzed intramolecular aryl guanidinylation.

KW - 1,3-benzodiazepines

KW - Pd(OAc)/Cu(OAc)

KW - cyclization

KW - guanidinylation

KW - solid-phase synthesis

UR - http://www.scopus.com/inward/record.url?scp=80052685519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052685519&partnerID=8YFLogxK

U2 - 10.1055/s-0030-1261186

DO - 10.1055/s-0030-1261186

M3 - Article

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SP - 2259

EP - 2261

JO - Synlett

JF - Synlett

IS - 15

M1 - W11911ST

ER -