Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives

Adel Nefzi; Nhi A. Ong; Marc A. Giulianotti; John M. Ostresh; Richard A. Houghten

doi:10.1016/S0040-4039(99)00964-8

Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives

Adel Nefzi, Nhi A. Ong, Marc A. Giulianotti, John M. Ostresh, Richard A. Houghten

Research output: Contribution to journal › Article › peer-review

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Abstract

The solid phase synthesis of 1,4-benzothiazepin-5-one derivatives, resulting from the reaction of resin-bound protected cysteine with 2-fluoro- 5-nitro-benzoic acid followed by a reductive alkylation and an intra molecular cyclization, is described.

Original language	English (US)
Pages (from-to)	4939-4942
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	27
DOIs	https://doi.org/10.1016/S0040-4039(99)00964-8
State	Published - Jul 2 1999
Externally published	Yes

Bibliographical note

Funding Information:
ACKNOWLEDGEMENTS We thank Eileen Weiler for editorial assistance. This work was funded in part by National Science Foundation Grant No. CHE-9520142 (I-Ioughten) and National Cancer Institute Grant No. 1P01CA78040 (Houghten). REFERENCES AND NOTES 1. For reviews on solid phase organic synthesis, see: (a) Gallop, M. A.; Barret, R. W.; Dower, W. J.; Fodor, S. P. A.; Gordon, E. M. Jr. Med, Chem.1 994, 37, 1233. (b) Gordon, E. M.; Barter, g. W.; Dower, W. J.;

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title = "Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives",

abstract = "The solid phase synthesis of 1,4-benzothiazepin-5-one derivatives, resulting from the reaction of resin-bound protected cysteine with 2-fluoro- 5-nitro-benzoic acid followed by a reductive alkylation and an intra molecular cyclization, is described.",

author = "Adel Nefzi and Ong, {Nhi A.} and Giulianotti, {Marc A.} and Ostresh, {John M.} and Houghten, {Richard A.}",

note = "Funding Information: ACKNOWLEDGEMENTS We thank Eileen Weiler for editorial assistance. This work was funded in part by National Science Foundation Grant No. CHE-9520142 (I-Ioughten) and National Cancer Institute Grant No. 1P01CA78040 (Houghten). REFERENCES AND NOTES 1. For reviews on solid phase organic synthesis, see: (a) Gallop, M. A.; Barret, R. W.; Dower, W. J.; Fodor, S. P. A.; Gordon, E. M. Jr. Med, Chem.1 994, 37, 1233. (b) Gordon, E. M.; Barter, g. W.; Dower, W. J.;",

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doi = "10.1016/S0040-4039(99)00964-8",

language = "English (US)",

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T1 - Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives

AU - Nefzi, Adel

AU - Ong, Nhi A.

AU - Giulianotti, Marc A.

AU - Ostresh, John M.

AU - Houghten, Richard A.

N1 - Funding Information: ACKNOWLEDGEMENTS We thank Eileen Weiler for editorial assistance. This work was funded in part by National Science Foundation Grant No. CHE-9520142 (I-Ioughten) and National Cancer Institute Grant No. 1P01CA78040 (Houghten). REFERENCES AND NOTES 1. For reviews on solid phase organic synthesis, see: (a) Gallop, M. A.; Barret, R. W.; Dower, W. J.; Fodor, S. P. A.; Gordon, E. M. Jr. Med, Chem.1 994, 37, 1233. (b) Gordon, E. M.; Barter, g. W.; Dower, W. J.;

PY - 1999/7/2

Y1 - 1999/7/2

N2 - The solid phase synthesis of 1,4-benzothiazepin-5-one derivatives, resulting from the reaction of resin-bound protected cysteine with 2-fluoro- 5-nitro-benzoic acid followed by a reductive alkylation and an intra molecular cyclization, is described.

AB - The solid phase synthesis of 1,4-benzothiazepin-5-one derivatives, resulting from the reaction of resin-bound protected cysteine with 2-fluoro- 5-nitro-benzoic acid followed by a reductive alkylation and an intra molecular cyclization, is described.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives

Abstract

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