Solid-phase synthesis and biological activity of the parallel dimer of deamino-oxytocin.

M. C. Munson, M. Lebl, J. Slaninová, G. Barany

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The parallel dimer of deamino-oxytocin has been synthesized by a novel solid-phase route. Successive orthogonal deprotection and oxidation reactions, carried out while the peptide remained anchored to a polymeric support, resulted in the formation of two disulfide bridges and conversion, with minimal side reactions, of the linear monomeric precursor to the dimer. The purified dimer showed approximately 0.1% to 2% of the biological activities of the monomer, as well as prolonged action. The time course of response to the deamino-oxytocin dimer differed from that of the monomer (and of oxytocin), and is probably due to slow formation of monomer under the conditions of biological testing.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalPeptide research
Volume6
Issue number3
StatePublished - 1993

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