Solid-phase syntheses of furopyridine and furoquinoline systems

Pablo Cironi; Judit Tulla-Puche; George Barany; Fernando Albericio; Mercedes Álvarez

doi:10.1021/ol049762f

Solid-phase syntheses of furopyridine and furoquinoline systems

Pablo Cironi, Judit Tulla-Puche, George Barany, Fernando Albericio, Mercedes Álvarez

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Syntheses of 2-substituted furo[3,2-b]pyridines and furo[3,2-h]quinolines have been achieved for the first time in the solid-phase mode. The central enabling steps involved concomitant deprotection/cyclization promoted by the mild base K₂CO₃. Reactions were monitored "in situ" in real time by a variety of spectroscopic techniques, which allowed full and accurate control of progress in these syntheses.

Original language	English (US)
Pages (from-to)	1405-1408
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	9
DOIs	https://doi.org/10.1021/ol049762f
State	Published - Apr 29 2004

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T1 - Solid-phase syntheses of furopyridine and furoquinoline systems

AU - Cironi, Pablo

AU - Tulla-Puche, Judit

AU - Barany, George

AU - Albericio, Fernando

AU - Álvarez, Mercedes

PY - 2004/4/29

Y1 - 2004/4/29

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AB - Syntheses of 2-substituted furo[3,2-b]pyridines and furo[3,2-h]quinolines have been achieved for the first time in the solid-phase mode. The central enabling steps involved concomitant deprotection/cyclization promoted by the mild base K2CO3. Reactions were monitored "in situ" in real time by a variety of spectroscopic techniques, which allowed full and accurate control of progress in these syntheses.

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Solid-phase syntheses of furopyridine and furoquinoline systems

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