Solid organ fabrication: Comparison of decellularization to 3D bioprinting

Jangwook P. Jung, Didarul B. Bhuiyan, Brenda M. Ogle

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Solid organ fabrication is an ultimate goal of Regenerative Medicine. Since the introduction of Tissue Engineering in 1993, functional biomaterials, stem cells, tunable microenvironments, and high-resolution imaging technologies have significantly advanced efforts to regenerate in vitro culture or tissue platforms. Relatively simple flat or tubular organs are already in (pre)clinical trials and a few commercial products are in market. The road to more complex, high demand, solid organs including heart, kidney and lung will require substantive technical advancement. Here, we consider two emerging technologies for solid organ fabrication. One is decellularization of cadaveric organs followed by repopulation with terminally differentiated or progenitor cells. The other is 3D bioprinting to deposit cell-laden bio-inks to attain complex tissue architecture. We reviewed the development and evolution of the two technologies and evaluated relative strengths needed to produce solid organs, with special emphasis on the heart and other tissues of the cardiovascular system.

Original languageEnglish (US)
Article number27
JournalBiomaterials Research
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Bioprinting
Technology
Fabrication
Tissue
Stem Cell Niche
Ink
Regenerative Medicine
Biocompatible Materials
Tissue Engineering
Cardiovascular System
Cardiovascular system
Stem Cells
Stem cells
Tissue engineering
Biomaterials
Clinical Trials
Kidney
Lung
Deposits
Imaging techniques

Keywords

  • 3D printing
  • Biomimetics
  • Decellularization
  • Extracellular matrix
  • Organogenesis

Cite this

Solid organ fabrication : Comparison of decellularization to 3D bioprinting. / Jung, Jangwook P.; Bhuiyan, Didarul B.; Ogle, Brenda M.

In: Biomaterials Research, Vol. 20, No. 1, 27, 01.01.2016.

Research output: Contribution to journalReview article

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