Social stress shortens lifespan in mice

Maria Razzoli, Kewir Nyuyki-Dufe, Allison Gurney, Connor Erickson, Jacob McCallum, Nicholas Spielman, Marta Marzullo, Jessica Patricelli, Morito Kurata, Emily A. Pope, Chadi Touma, Rupert Palme, David A. Largaespada, David B. Allison, Alessandro Bartolomucci

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Stress and low socioeconomic status in humans confer increased vulnerability to morbidity and mortality. However, this association is not mechanistically understood nor has its causation been explored in animal models thus far. Recently, cellular senescence has been suggested as a potential mechanism linking lifelong stress to age-related diseases and shorter life expectancy in humans. Here, we established a causal role for lifelong social stress on shortening lifespan and increasing the risk of cardiovascular disease in mice. Specifically, we developed a lifelong chronic psychosocial stress model in which male mouse aggressive behavior is used to study the impact of negative social confrontations on healthspan and lifespan. C57BL/6J mice identified through unbiased cluster analysis for receiving high while exhibiting low aggression, or identified as subordinate based on an ethologic criterion, had lower median and maximal lifespan, and developed earlier onset of several organ pathologies in the presence of a cellular senescence signature. Critically, subordinate mice developed spontaneous early-stage atherosclerotic lesions of the aortic sinuses characterized by significant immune cells infiltration and sporadic rupture and calcification, none of which was found in dominant subjects. In conclusion, we present here the first rodent model to study and mechanistically dissect the impact of chronic stress on lifespan and disease of aging. These data highlight a conserved role for social stress and low social status on shortening lifespan and increasing the risk of cardiovascular disease in mammals and identify a potential mechanistic link for this complex phenomenon.

Original languageEnglish (US)
Article numbere12778
JournalAging cell
Issue number4
StatePublished - Aug 2018

Bibliographical note

Funding Information:
Supported by NIH/NIA AG043972 (D.A., A.B.), NIH/NIDDK DK102496 (A.B.), Fesler-Lampert Chair in Aging Studies, Center on Aging, University of Minnesota (A.B), American Cancer Society Research Professor Award (D.A.L.). Authors wish to thank S. Pletcher for critical comments, K. Kaiser, A. Patki, and D.L. Smith Jr for statistical advice and help with the experimental design, L. Anderson, C. Acosta, C. Ayers, R. Heuer, C. Cero, J. Asturias, A. Jain, D. Svedberg, and B. Sahu for help with the study, T. Wietecha and the University of Washington Pathology Core Facility for the heart morphometric analysis and IHC.

Publisher Copyright:
© 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.


  • aggression
  • atherosclerosis
  • healthspan
  • lifespan
  • senescence
  • stress


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