Social networks predict gut microbiome composition in wild baboons

Jenny Tung, Luis B. Barreiro, Michael B. Burns, Jean Christophe Grenier, Josh Lynch, Laura E. Grieneisen, Jeanne Altmann, Susan C. Alberts, Ran Blekhman, Elizabeth A. Archie

Research output: Contribution to journalArticlepeer-review

226 Scopus citations

Abstract

Social relationships have profound effects on health in humans and other primates, but the mechanisms that explain this relationship are notwell understood. Using shotgun metagenomic data from wild baboons, we found that social group membership and social network relationships predicted both the taxonomic structure of the gut microbiome and the structure of genes encoded by gut microbial species. Rates of interaction directly explained variation in the gut microbiome, even after controlling for diet, kinship, and shared environments. They therefore strongly implicate direct physical contact among social partners in the transmission of gut microbial species. We identified 51 socially structured taxa, which were significantly enriched for anaerobic and non-spore-forming lifestyles. Our results argue that social interactions are an important determinant of gut microbiome composition in natural animal populations—a relationship with important ramifications for understanding how social relationships influence health, as well as the evolution of group living.

Original languageEnglish (US)
Article numbere05224
JournaleLife
Volume2015
Issue number4
DOIs
StatePublished - Mar 17 2015

Bibliographical note

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© 2015, eLife Sciences Publications Ltd. All rights reserved.

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