Abstract
BACKGROUND AND PURPOSE -: Having a small social network and lack of social support have been associated with incident coronary heart disease; however, epidemiological evidence for incident stroke is limited. We assessed the longitudinal association of a small social network and lack of social support with risk of incident stroke and evaluated whether the association was partly mediated by vital exhaustion and inflammation. METHODS -: The Atherosclerosis Risk in Communities study measured social network and social support in 13 686 men and women (mean, 57 years; 56% women; 24% black; 76% white) without a history of stroke. Social network was assessed by the 10-item Lubben Social Network Scale and social support by a 16-item Interpersonal Support Evaluation List-Short Form. RESULTS -: During a median follow-up of 18.6 years, 905 incident strokes occurred. Relative to participants with a large social network, those with a small social network had a higher risk of stroke (hazard ratio [95% confidence interval], 1.44 [1.02-2.04]) after adjustment for demographics, socioeconomic variables, marital status, behavioral risk factors, and major stroke risk factors. Vital exhaustion, but not inflammation, partly mediated the association between a small social network and incident stroke. Social support was unrelated to incident stroke. CONCLUSIONS -: In this sample of US community-dwelling men and women, having a small social network was associated with excess risk of incident stroke. As with other cardiovascular conditions, having a small social network may be associated with a modestly increased risk of incident stroke.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2868-2873 |
| Number of pages | 6 |
| Journal | Stroke |
| Volume | 45 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 12 2014 |
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Keywords
- epidemiology
- inflammation
- social support
- stroke
Cite this
Social network, social support, and risk of incident stroke : Atherosclerosis risk in communities study. / Nagayoshi, Mako; Everson-Rose, Susan A.; Iso, Hiroyasu; Mosley, Thomas H.; Rose, Kathryn M.; Lutsey, Pamela L.
In: Stroke, Vol. 45, No. 10, 12.10.2014, p. 2868-2873.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Social network, social support, and risk of incident stroke
T2 - Atherosclerosis risk in communities study
AU - Nagayoshi, Mako
AU - Everson-Rose, Susan A.
AU - Iso, Hiroyasu
AU - Mosley, Thomas H.
AU - Rose, Kathryn M.
AU - Lutsey, Pamela L.
PY - 2014/10/12
Y1 - 2014/10/12
N2 - BACKGROUND AND PURPOSE -: Having a small social network and lack of social support have been associated with incident coronary heart disease; however, epidemiological evidence for incident stroke is limited. We assessed the longitudinal association of a small social network and lack of social support with risk of incident stroke and evaluated whether the association was partly mediated by vital exhaustion and inflammation. METHODS -: The Atherosclerosis Risk in Communities study measured social network and social support in 13 686 men and women (mean, 57 years; 56% women; 24% black; 76% white) without a history of stroke. Social network was assessed by the 10-item Lubben Social Network Scale and social support by a 16-item Interpersonal Support Evaluation List-Short Form. RESULTS -: During a median follow-up of 18.6 years, 905 incident strokes occurred. Relative to participants with a large social network, those with a small social network had a higher risk of stroke (hazard ratio [95% confidence interval], 1.44 [1.02-2.04]) after adjustment for demographics, socioeconomic variables, marital status, behavioral risk factors, and major stroke risk factors. Vital exhaustion, but not inflammation, partly mediated the association between a small social network and incident stroke. Social support was unrelated to incident stroke. CONCLUSIONS -: In this sample of US community-dwelling men and women, having a small social network was associated with excess risk of incident stroke. As with other cardiovascular conditions, having a small social network may be associated with a modestly increased risk of incident stroke.
AB - BACKGROUND AND PURPOSE -: Having a small social network and lack of social support have been associated with incident coronary heart disease; however, epidemiological evidence for incident stroke is limited. We assessed the longitudinal association of a small social network and lack of social support with risk of incident stroke and evaluated whether the association was partly mediated by vital exhaustion and inflammation. METHODS -: The Atherosclerosis Risk in Communities study measured social network and social support in 13 686 men and women (mean, 57 years; 56% women; 24% black; 76% white) without a history of stroke. Social network was assessed by the 10-item Lubben Social Network Scale and social support by a 16-item Interpersonal Support Evaluation List-Short Form. RESULTS -: During a median follow-up of 18.6 years, 905 incident strokes occurred. Relative to participants with a large social network, those with a small social network had a higher risk of stroke (hazard ratio [95% confidence interval], 1.44 [1.02-2.04]) after adjustment for demographics, socioeconomic variables, marital status, behavioral risk factors, and major stroke risk factors. Vital exhaustion, but not inflammation, partly mediated the association between a small social network and incident stroke. Social support was unrelated to incident stroke. CONCLUSIONS -: In this sample of US community-dwelling men and women, having a small social network was associated with excess risk of incident stroke. As with other cardiovascular conditions, having a small social network may be associated with a modestly increased risk of incident stroke.
KW - epidemiology
KW - inflammation
KW - social support
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=84922481842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922481842&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.114.005815
DO - 10.1161/STROKEAHA.114.005815
M3 - Article
C2 - 25139878
AN - SCOPUS:84922481842
VL - 45
SP - 2868
EP - 2873
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 10
ER -