Smoking-related symptomatology in pregnant smokers during ad libitum smoking and following overnight smoking abstinence

Sharon Allen; Katherine Harrison; Ashley Petersen; Jane Goodson

doi:10.1186/s13104-019-4503-x

Smoking-related symptomatology in pregnant smokers during ad libitum smoking and following overnight smoking abstinence

Sharon Allen, Katherine Harrison, Ashley Petersen, Jane Goodson

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Current literature suggests there may be a relationship between sex hormones, which dramatically increase during pregnancy, and nicotine use behaviors. We hypothesized that higher progesterone and progesterone:estradiol ratio (P/E₂) would be associated with less smoking-related symptomatology (SRS), better mood and fewer cigarettes smoked per day (CPD) during ad libitum smoking and following overnight abstinence in pregnant women. Associations between SRS, mood, smoking behavior and sex hormones were estimated using multiple linear regression with adjustment for CPD and pregnancy trimester. Results: There were 35 second trimester and 42 third trimester participants. Participants mean age was 26.2 (SD: 4.1), they smoked 11.3 CPD (SD: 4.4) and the mean nicotine dependence score was 4.94 (SD: 1.98). There were no statistically significant associations between progesterone levels, estradiol levels, or the P/E₂ ratio and SRS or mood measures during ad libitum smoking or following overnight abstinence in this sample of pregnant women. Similarly, there were no associations between sex hormone levels and number of CPD smoked during the ad libitum period. Contrary to our hypothesis, we found no significant associations between sex hormones and SRS, mood or smoking behavior in this sample of pregnant women. Trial registration ClinicalTrials.gov

Original language	English (US)
Article number	473
Journal	BMC Research Notes
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/s13104-019-4503-x
State	Published - Aug 1 2019

Bibliographical note

Funding Information:
We extend our thanks to Brittany Niesen for her dedication to recruitment and data collection. We also thank Dr. Frank Stanczyk, a Professor of Research, Obstetrics and Gynecology, and Preventive Medicine and Director of the Reproductive Endocrine Research Laboratory at the University of Southern California’s Keck School of Medicine, for his expertise in the analysis of serum hormone samples. This work was supported by MEI research who provided data management and development support for our EMA data collection tools.

Funding Information:
Support for this project was provided by the National Institute on Drug Abuse (R01DA08075). The funding agency did not participate in the design of the study, in the collection, analysis, or interpretation of the data, or in the writing of this manuscript. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2019 The Author(s).

Keywords

Pregnancy
Sex hormones
Smoking-related symptomatology
Tobacco

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1186/s13104-019-4503-x

Find It

Find It at U of M Libraries

Cite this

@article{6ddae035fdb24fb092d6954cd032e5e3,

title = "Smoking-related symptomatology in pregnant smokers during ad libitum smoking and following overnight smoking abstinence",

abstract = "Objective: Current literature suggests there may be a relationship between sex hormones, which dramatically increase during pregnancy, and nicotine use behaviors. We hypothesized that higher progesterone and progesterone:estradiol ratio (P/E2) would be associated with less smoking-related symptomatology (SRS), better mood and fewer cigarettes smoked per day (CPD) during ad libitum smoking and following overnight abstinence in pregnant women. Associations between SRS, mood, smoking behavior and sex hormones were estimated using multiple linear regression with adjustment for CPD and pregnancy trimester. Results: There were 35 second trimester and 42 third trimester participants. Participants mean age was 26.2 (SD: 4.1), they smoked 11.3 CPD (SD: 4.4) and the mean nicotine dependence score was 4.94 (SD: 1.98). There were no statistically significant associations between progesterone levels, estradiol levels, or the P/E2 ratio and SRS or mood measures during ad libitum smoking or following overnight abstinence in this sample of pregnant women. Similarly, there were no associations between sex hormone levels and number of CPD smoked during the ad libitum period. Contrary to our hypothesis, we found no significant associations between sex hormones and SRS, mood or smoking behavior in this sample of pregnant women. Trial registration ClinicalTrials.gov",

keywords = "Pregnancy, Sex hormones, Smoking-related symptomatology, Tobacco",

author = "Sharon Allen and Katherine Harrison and Ashley Petersen and Jane Goodson",

note = "Funding Information: We extend our thanks to Brittany Niesen for her dedication to recruitment and data collection. We also thank Dr. Frank Stanczyk, a Professor of Research, Obstetrics and Gynecology, and Preventive Medicine and Director of the Reproductive Endocrine Research Laboratory at the University of Southern California{\textquoteright}s Keck School of Medicine, for his expertise in the analysis of serum hormone samples. This work was supported by MEI research who provided data management and development support for our EMA data collection tools. Funding Information: Support for this project was provided by the National Institute on Drug Abuse (R01DA08075). The funding agency did not participate in the design of the study, in the collection, analysis, or interpretation of the data, or in the writing of this manuscript. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2019 The Author(s).",

year = "2019",

month = aug,

day = "1",

doi = "10.1186/s13104-019-4503-x",

language = "English (US)",

volume = "12",

journal = "BMC Research Notes",

issn = "1756-0500",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Smoking-related symptomatology in pregnant smokers during ad libitum smoking and following overnight smoking abstinence

AU - Allen, Sharon

AU - Harrison, Katherine

AU - Petersen, Ashley

AU - Goodson, Jane

N1 - Funding Information: We extend our thanks to Brittany Niesen for her dedication to recruitment and data collection. We also thank Dr. Frank Stanczyk, a Professor of Research, Obstetrics and Gynecology, and Preventive Medicine and Director of the Reproductive Endocrine Research Laboratory at the University of Southern California’s Keck School of Medicine, for his expertise in the analysis of serum hormone samples. This work was supported by MEI research who provided data management and development support for our EMA data collection tools. Funding Information: Support for this project was provided by the National Institute on Drug Abuse (R01DA08075). The funding agency did not participate in the design of the study, in the collection, analysis, or interpretation of the data, or in the writing of this manuscript. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2019 The Author(s).

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Objective: Current literature suggests there may be a relationship between sex hormones, which dramatically increase during pregnancy, and nicotine use behaviors. We hypothesized that higher progesterone and progesterone:estradiol ratio (P/E2) would be associated with less smoking-related symptomatology (SRS), better mood and fewer cigarettes smoked per day (CPD) during ad libitum smoking and following overnight abstinence in pregnant women. Associations between SRS, mood, smoking behavior and sex hormones were estimated using multiple linear regression with adjustment for CPD and pregnancy trimester. Results: There were 35 second trimester and 42 third trimester participants. Participants mean age was 26.2 (SD: 4.1), they smoked 11.3 CPD (SD: 4.4) and the mean nicotine dependence score was 4.94 (SD: 1.98). There were no statistically significant associations between progesterone levels, estradiol levels, or the P/E2 ratio and SRS or mood measures during ad libitum smoking or following overnight abstinence in this sample of pregnant women. Similarly, there were no associations between sex hormone levels and number of CPD smoked during the ad libitum period. Contrary to our hypothesis, we found no significant associations between sex hormones and SRS, mood or smoking behavior in this sample of pregnant women. Trial registration ClinicalTrials.gov

AB - Objective: Current literature suggests there may be a relationship between sex hormones, which dramatically increase during pregnancy, and nicotine use behaviors. We hypothesized that higher progesterone and progesterone:estradiol ratio (P/E2) would be associated with less smoking-related symptomatology (SRS), better mood and fewer cigarettes smoked per day (CPD) during ad libitum smoking and following overnight abstinence in pregnant women. Associations between SRS, mood, smoking behavior and sex hormones were estimated using multiple linear regression with adjustment for CPD and pregnancy trimester. Results: There were 35 second trimester and 42 third trimester participants. Participants mean age was 26.2 (SD: 4.1), they smoked 11.3 CPD (SD: 4.4) and the mean nicotine dependence score was 4.94 (SD: 1.98). There were no statistically significant associations between progesterone levels, estradiol levels, or the P/E2 ratio and SRS or mood measures during ad libitum smoking or following overnight abstinence in this sample of pregnant women. Similarly, there were no associations between sex hormone levels and number of CPD smoked during the ad libitum period. Contrary to our hypothesis, we found no significant associations between sex hormones and SRS, mood or smoking behavior in this sample of pregnant women. Trial registration ClinicalTrials.gov

KW - Pregnancy

KW - Sex hormones

KW - Smoking-related symptomatology

KW - Tobacco

UR - http://www.scopus.com/inward/record.url?scp=85070278654&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070278654&partnerID=8YFLogxK

U2 - 10.1186/s13104-019-4503-x

DO - 10.1186/s13104-019-4503-x

M3 - Article

C2 - 31370907

AN - SCOPUS:85070278654

SN - 1756-0500

VL - 12

JO - BMC Research Notes

JF - BMC Research Notes

IS - 1

M1 - 473

ER -

Smoking-related symptomatology in pregnant smokers during ad libitum smoking and following overnight smoking abstinence

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this