Small is the new big-interplay of miRNAs in cancer

Jyotika Varshney, Subbaya Subramanian

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

MicroRNAs (miRNAs) are small non-coding regulatory RNAs that post-transcriptionally regulate gene expression. About 1500 miRNAs have been discovered in humans and these can target and regulate up to 60% of coding genes. MicroRNAs play a key role in all cellular functions and are implicated in most diseases, including cancer. Deregulation of microRNA expression can affect various metabolic and signalling pathways and results in cancer development and progression. This review provides a comprehensive view of various cancer types and their associated microRNAs.

Original languageEnglish (US)
Pages (from-to)803-814
Number of pages12
JournalCurrent Science
Volume107
Issue number5
StatePublished - Jan 1 2014

Keywords

  • Cancer subtypes
  • Deregulation
  • Gene expression
  • MicroRNAs

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