Smad2 protects against TGF-β/Smad3-mediated renal fibrosis

Keyphrases

• Renal Fibrosis 100%
• Smad2 100%
• Smad3 100%
• Fibrosis 40%
• TGF-1 30%
• Renal Tubular Epithelial Cells 20%
• Collagen I 20%
• Smad3 Phosphorylation 20%
• Overexpression 10%
• Collagen 10%
• Fibroblasts 10%
• Knockdown 10%
• Matrix metalloproteinase-2 (MMP-2) 10%
• Tissue Inhibitor of metalloproteinase-1 (TIMP-1) 10%
• Promoter Activity 10%
• Nuclear Translocation 10%
• Decreased Expression 10%
• Conditional Deletion 10%
• Promoter Binding 10%
• TGF Signaling 10%
• COL1A2 10%
• Fibrogenesis 10%
• Matrix Expression 10%
• Matrix-degrading Enzymes 10%
• Kidney Tubular Cells 10%
• Collagen III 10%
• I-matrix 10%
• Unilateral Ureteral Obstruction 10%
• Autoinduction 10%

Biochemistry, Genetics and Molecular Biology

• Promoter Region 100%
• Wild Type 50%
• COL1A2 50%
• Autoinduction 50%
• Enzyme 50%
• Fibrogenesis 50%
• Gelatinase A 50%
• MMP2 50%
• Metalloprotease Inhibitor 50%
• Fibroblast 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Kidney Fibrosis 100%
• Fibrosis 100%
• Gelatinase A 25%
• Tissue Inhibitor of Metalloproteinase 25%
• Ureter Obstruction 25%