Slowing progression of chronic kidney disease

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Early identification of chronic kidney disease (CKD) provides an opportunity to implement therapies to improve kidney function and slow progression. The goal of this article is to review established and developing clinical therapies directed at slowing progression. The importance of controlling blood pressure will be discussed along with the target blood pressure that should be achieved in CKD patients. Therapy directed at inhibiting the renin-angiotensin-aldosterone system remains the mainstay of treatment with single-agent inhibition of this system being as good as dual blockade with fewer adverse effects. Other therapies that may be used include correction of metabolic acidosis, dietary protein restriction, and new models for delivering care to patients with CKD. Emerging therapies targeting endothelin, uric acid, kidney fibrosis, and oxidant stress hold promise for the future.

Original languageEnglish (US)
Pages (from-to)372-376
Number of pages5
JournalKidney International Supplements
Volume3
Issue number4
DOIs
StatePublished - Dec 1 2013

Keywords

  • Blood pressure target
  • chronic kidney disease
  • endothelin
  • progression
  • renin-angiotensin-aldosterone

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