Slow virus visna: Reproduction in vitro of virus from extrachromosomal DNA

J. D. Harris, H. Blum, J. Scott, B. Traynor, P. Ventura, A. Haase

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Under permissive conditions of growth in tissue culture, the retrovirus visna multiplies over the course of a few days to high titer and kills the host cell. We show that in this lytic life cycle, viral DNA is tightly associated with, but not covalently linked to, chromosomal DNA. This finding provides explanations for a number of the unusual properties of the lentivirus subfamily of retroviruses, and suggests potential mechanisms for the block in virus gene expression in vivo responsible for the slow infection in nature.

Original languageEnglish (US)
Pages (from-to)7212-7215
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume81
Issue number22 I
DOIs
StatePublished - 1984

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