Sleep-wake effects of yohimbine and atropine in rats with a clomipramine-based model of depression

Vijayakumar Mavanji, Subimal Datta

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The present study examined the sleep-wake cycle effects of microinjections of yohimbine, an adrenergic antagonist, and atropine, a cholinergic antagonist, into the cerebral ventricle of clomipramine-induced depressed rats. Yohimbine microinjection caused a significant reduction in the total duration and the number of REM sleep episodes compared to control saline injections. Atropine microinjection caused a significant reduction in the total duration and the number of REM sleep episodes without changing the REM sleep latency compared to control saline microinjection. These results show for the first time that the REM sleep disturbances observed in clomipramine-treatment induced depressed rats can be attenuated by increasing and decreasing the brain noradrenergic and cholinergic activities, respectively.

Original languageEnglish (US)
Pages (from-to)1603-1606
Number of pages4
JournalNeuroreport
Volume13
Issue number13
DOIs
StatePublished - Sep 16 2002
Externally publishedYes

Keywords

  • Animal model
  • Atropine
  • Endogenous depression
  • REM sleep
  • Yohimbine

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