Skeletal muscle plasticity after hemorrhagic stroke in rats

Leann M. Snow, Walter C. Low, Ladora V. Thompson

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12 Scopus citations


Snow LM, Low WC, Thompson LV: Skeletal muscle plasticity after hemorrhagic stroke in rats: influence of spontaneous physical activity. Am J Phys Med Rehabil 2012;91:965Y976. Objective: The aim of this study was to determine the contribution of spontaneous post-stroke physical activity to skeletal muscle plasticity after stroke. Design: A randomized controlled study was conducted of 24 young adult male Sprague-Dawley rats assigned to three experimental groups: (1) STRVhemorrhagic stroke in the right caudoputamen; (2) SHAMVprocedural control; and (3) CONTVno intervention (n = 8/group). Neurologic testing was performed before and 2 wks after stroke. Spontaneous physical activity was monitored five nights per week for 1 wk preoperatively and 2 wks postoperatively. Two weeks after stroke induction, bilateral soleus and tibialis anterior muscles were harvested. Myofiber cross-sectional areas were determined, and fiber typing was performed with immunohistochemistry. Results: STR animals demonstrated neurologic deficit in the contralesional hindlimb 2 wks after stroke. Quantity of spontaneous physical activity did not differ between groups within each of the week-long study intervals. No significant difference was found in fiber types or cross-sectional areas in the soleus muscle of STR vs. CONT groups. However, the tibialis anterior muscle of the contralesional hindlimbs of the STR animals showed atrophy in 2x and 1 + 2x myofibers, as well as type 1 hypertrophy. Conclusions: Skeletal muscle adaptation occurs by 2 wks post-stroke in this model. It is muscle specific and appears to be influenced by factors other than spontaneous post-stroke physical activity.

Original languageEnglish (US)
Pages (from-to)965-976
Number of pages12
JournalAmerican Journal of Physical Medicine and Rehabilitation
Issue number11
StatePublished - Nov 2012


  • Immunohistochemistry
  • Rehabilitation
  • Skeletal Muscle
  • Stroke


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