Abstract
Sjögren's syndrome (SS) is a progressive autoimmune rheumatic disorder.1-6 Its precise etiology is unknown, although several contributing factors have been identified. One theory is that the condition results from complications related to infection with the Epstein-Barr virus.4 Primary exposure to or reactivation of Epstein-Barr virus elicits expression of the human leukocyte antigen complex. This is recognized by T lymphocytes (CD 4+) resulting in the release of cytokines (tumor necrosis factor, interleukin-2, interferon-gamma, and others). A genetic marker specific for Sjögren's syndrome, HLA-DR4, has been identified.1,2 According to the World Health Organization, the prevalence of Sjögren 's syndrome is unknown.7 A recent epidemiologic study in Sweden estimated the prevalence in the adult population to be 2.7%.8 In the United States, 10 years ago, the number of patients with Sjögren's syndrome was thought to be fewer than 100,000.9 This number today is estimated to be more than 1 million.10 Sjögren's syndrome has been reported in nearly every major country of the world, and the geographic distribution of cases appears to be relatively uniform.11 Sjögren's syndrome typically affects women (90%) during the fourth or fifth decade of life.12 Isolated cases of Sjögren's syndrome in children have been reported.13.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 689-699 |
| Number of pages | 11 |
| Journal | Quintessence International |
| Volume | 30 |
| Issue number | 10 |
| State | Published - Oct 1 1999 |
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Sjögren's syndrome. / Rhodus, Nelson L.
In: Quintessence International, Vol. 30, No. 10, 01.10.1999, p. 689-699.Research output: Contribution to journal › Short survey
}
TY - JOUR
T1 - Sjögren's syndrome
AU - Rhodus, Nelson L
PY - 1999/10/1
Y1 - 1999/10/1
N2 - Sjögren's syndrome (SS) is a progressive autoimmune rheumatic disorder.1-6 Its precise etiology is unknown, although several contributing factors have been identified. One theory is that the condition results from complications related to infection with the Epstein-Barr virus.4 Primary exposure to or reactivation of Epstein-Barr virus elicits expression of the human leukocyte antigen complex. This is recognized by T lymphocytes (CD 4+) resulting in the release of cytokines (tumor necrosis factor, interleukin-2, interferon-gamma, and others). A genetic marker specific for Sjögren's syndrome, HLA-DR4, has been identified.1,2 According to the World Health Organization, the prevalence of Sjögren 's syndrome is unknown.7 A recent epidemiologic study in Sweden estimated the prevalence in the adult population to be 2.7%.8 In the United States, 10 years ago, the number of patients with Sjögren's syndrome was thought to be fewer than 100,000.9 This number today is estimated to be more than 1 million.10 Sjögren's syndrome has been reported in nearly every major country of the world, and the geographic distribution of cases appears to be relatively uniform.11 Sjögren's syndrome typically affects women (90%) during the fourth or fifth decade of life.12 Isolated cases of Sjögren's syndrome in children have been reported.13.
AB - Sjögren's syndrome (SS) is a progressive autoimmune rheumatic disorder.1-6 Its precise etiology is unknown, although several contributing factors have been identified. One theory is that the condition results from complications related to infection with the Epstein-Barr virus.4 Primary exposure to or reactivation of Epstein-Barr virus elicits expression of the human leukocyte antigen complex. This is recognized by T lymphocytes (CD 4+) resulting in the release of cytokines (tumor necrosis factor, interleukin-2, interferon-gamma, and others). A genetic marker specific for Sjögren's syndrome, HLA-DR4, has been identified.1,2 According to the World Health Organization, the prevalence of Sjögren 's syndrome is unknown.7 A recent epidemiologic study in Sweden estimated the prevalence in the adult population to be 2.7%.8 In the United States, 10 years ago, the number of patients with Sjögren's syndrome was thought to be fewer than 100,000.9 This number today is estimated to be more than 1 million.10 Sjögren's syndrome has been reported in nearly every major country of the world, and the geographic distribution of cases appears to be relatively uniform.11 Sjögren's syndrome typically affects women (90%) during the fourth or fifth decade of life.12 Isolated cases of Sjögren's syndrome in children have been reported.13.
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M3 - Short survey
VL - 30
SP - 689
EP - 699
JO - Quintessence international (Berlin, Germany : 1985)
JF - Quintessence international (Berlin, Germany : 1985)
SN - 0033-6572
IS - 10
ER -