TY - JOUR
T1 - Size of Antibody and Role of Autonomic Nervous System in the Adjuvant Action of Endotoxin
AU - Rosenblatt, Elwood
AU - Johnson, Arthur G.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1963/5
Y1 - 1963/5
N2 - Stimulation by endotoxin of the primary antibody response to bovine gamma globulin in rabbits results initially in antibody of the 19S class, and later, in part, of antibody of the 7S class. In some instances, 19S antibody constituted the entire primary response. (2) In the rabbit the sympathetic nervous system did not appear to be involved in the antibody-enhancing effect of endotoxin, in that the adrenergic blocking agent, dibenzyline, did not inhibit antibody enhancement, nor did epinephrine given intravenously potentiate antibody formation. (3) The hemagglutinating antibody titer did not correlate with the precipitating antibody titer.
AB - Stimulation by endotoxin of the primary antibody response to bovine gamma globulin in rabbits results initially in antibody of the 19S class, and later, in part, of antibody of the 7S class. In some instances, 19S antibody constituted the entire primary response. (2) In the rabbit the sympathetic nervous system did not appear to be involved in the antibody-enhancing effect of endotoxin, in that the adrenergic blocking agent, dibenzyline, did not inhibit antibody enhancement, nor did epinephrine given intravenously potentiate antibody formation. (3) The hemagglutinating antibody titer did not correlate with the precipitating antibody titer.
UR - https://www.scopus.com/pages/publications/73649191636
UR - https://www.scopus.com/pages/publications/73649191636#tab=citedBy
U2 - 10.3181/00379727-113-28305
DO - 10.3181/00379727-113-28305
M3 - Article
C2 - 13974917
AN - SCOPUS:73649191636
SN - 0037-9727
VL - 113
SP - 156
EP - 161
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 1
ER -