Size of Antibody and Role of Autonomic Nervous System in the Adjuvant Action of Endotoxin

Elwood Rosenblatt, Arthur G. Johnson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Stimulation by endotoxin of the primary antibody response to bovine gamma globulin in rabbits results initially in antibody of the 19S class, and later, in part, of antibody of the 7S class. In some instances, 19S antibody constituted the entire primary response. (2) In the rabbit the sympathetic nervous system did not appear to be involved in the antibody-enhancing effect of endotoxin, in that the adrenergic blocking agent, dibenzyline, did not inhibit antibody enhancement, nor did epinephrine given intravenously potentiate antibody formation. (3) The hemagglutinating antibody titer did not correlate with the precipitating antibody titer.

Original languageEnglish (US)
Pages (from-to)156-161
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume113
Issue number1
DOIs
StatePublished - May 1963

Bibliographical note

Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.

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