siRNAs: their potential as therapeutic agents - Part I. Designing of siRNAs

Praveensingh B. Hajeri, Sunit Kumar Singh

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

RNA interference (RNAi) is a novel and essential biological process, as well as a powerful experimental tool with the potential to be used in therapeutic development. RNAi-based strategies have the capability of being able to be driven from bench to bedside. It is very important to develop the precise tools for designing the siRNAs to get the most efficient knockdown of the target genes and to reduce any off-target effects. In this review we have discussed the strategies and parameters required for effective siRNA designing and synthesis, based on already published literature.

Original languageEnglish (US)
Pages (from-to)851-858
Number of pages8
JournalDrug Discovery Today
Volume14
Issue number17-18
DOIs
StatePublished - Sep 2009

Bibliographical note

Funding Information:
Authors are highly thankful to Dr Lalji Singh, Director, Centre for Cellular & Molecular Biology (CCMB), Hyderabad for providing all the necessary support during the preparation of this manuscript. The financial support (Ref: BT/PR10709/AGR/36/598/2008) from the Department of Biotechnology (DBT), Govt. of India, New Delhi is highly acknowledged.

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

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