siRecords: An extensive database of mammalian siRNAs with efficacy ratings

Yongliang Ren, Wuming Gong, Qiqi Xu, Xin Zheng, Dong Lin, Yejun Wang, Tongbin Li

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Summary: Short interfering RNAs (siRNAs) have been gaining popularity as the gene knock-down tool of choice by many researchers because of the clean nature of their workings as well as the technical simplicity and cost efficiency in their applications. We have constructed siRecords, a database of siRNAs experimentally tested by researchers with consistent efficacy ratings. This database will help siRNA researchers develop more reliable siRNA design rules; in the mean time, siRecords will benefit experimental researchers directly by providing them with information about the siRNAs that have been experimentally tested against the genes of their interest. Currently, more than 4100 carefully annotated siRNA sequences obtained from more than 1200 published siRNA studies are hosted in siRecords. This database will continue to expand as more experimentally tested siRNAs are published.

Original languageEnglish (US)
Pages (from-to)1027-1028
Number of pages2
Issue number8
StatePublished - Apr 2006

Bibliographical note

Funding Information:
The authors thank S. Li and W. Liu for technical assistance and helpful discussions. They also thank the Supercomputing Institute, University of Minnesota for providing computing resources. This work was supported in part by the University of Minnesota Graduate School.

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