Sintering technique for the preparation of polymer matrices for the controlled release of macromolecules

Jonathan Cohen, Ronald A. Siegel, Robert Langer

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31 Scopus citations


A new method for making polymeric systems for the controlled release of macromolecular drugs is described. The method consists of mixing drug and polymer (ethylene‐vinyl acetate copolymer) powders below the glass transition temperature of the polymer and compressing the mixture at a temperature above the glass transition point. The macromolecule is not exposed to organic solvent during the fabrication process. Kinetic studies indicate that there is sustained release, and the bioactivity of macromolecules tested is unchanged throughout the sintering and release processes.

Original languageEnglish (US)
Pages (from-to)1034-1037
Number of pages4
JournalJournal of Pharmaceutical Sciences
Issue number8
StatePublished - Aug 1984

Bibliographical note

Funding Information:
This study was supported by Grant AM 16694 from the National Institute of Arthritis, Metabolism and Digestive Diseases.

Funding Information:
This work was funded by Grant GM26698 from the National Institutes of Health.


  • Copolymers—ethylene‐vinyl acetate, controlled release of macromolecules
  • Sintering technique—preparation of ethylene‐vinyl acetate copolymer, controlled release of macromolecules
  • Sustained release—macromolecules, ethylene‐vinyl acetate copolymer


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