Single Versus Bilateral Lung Transplantation for Idiopathic Pulmonary Fibrosis in the Lung Allocation Score Era

John R. Spratt, Rade Tomic, Roland Z. Brown, Kyle Rudser, Gabriel Loor, Marshall Hertz, Sara Shumway, Rosemary F. Kelly

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease. Lung transplantation is the only therapy associated with prolonged survival. The ideal transplant procedure for IPF is unclear. Outcomes after single transplantation (SLTx) versus bilateral lung transplantation (BLTx) in IPF patients after introduction of the Lung Allocation Score were examined. Methods: Records of patients undergoing lung transplantation for IPF at our institution between May 2005 and March 2017 were reviewed to examine the effect of transplant laterality. Primary outcomes were overall, rejection-free, and bronchiolitis obliterans (BOS)-free survival at 1 and 5 years post-transplant. Results: Lung transplantation was performed in 151 IPF patients post-Lung Allocation Score. Most recipients were male with average age 59 ± 8 years. SLTx was performed in 94 patients (62%). In the overall cohort, comparative survival between SLTx and BLTx was similar at 1 and 5 years before and after adjusting for age and pulmonary hypertension (PH). SLTx was associated with shorter ventilator time and intensive care unit stay and trended toward improved survival over BLTx in patients without PH. Conclusions: The use of SLTx versus BLTx in IPF did not correspond to significantly different survival adjusting for age and PH. BLTx was associated with prolonged postoperative ventilation and length of stay compared with SLTx. Patients without PH, all older patients, and patients with PH and advanced disease should be considered for SLTx for IPF.

Original languageEnglish (US)
Pages (from-to)84-95
Number of pages12
JournalJournal of Surgical Research
StatePublished - Feb 2019

Bibliographical note

Funding Information:
This work was supported in part by award UL1TR000114 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH). These funding organizations did not have any role in collecting, analyzing, or interpreting data or the decision to publish the manuscript.

Publisher Copyright:
© 2018 Elsevier Inc.


  • Idiopathic pulmonary fibrosis
  • Interstitial lung disease
  • Lung transplantation


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