Single unit studies of identified bulbospinal serotonergic units

Martin W. Wessendorf, Edmund G. Anderson

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Non-serotonergic bulbospinal neurons were identified by conduction velocities greater than 6 m/s. These units were found to fire at rates from 0 to 22 Hz, to respond to sensory stimuli with either excitation or inhibition, and to have unremarkable spike shapes. In iontophoretic experiments, both excitation and inhibition were observed in response to acetylcholine, norepinephrine and serotonin. Serotonergic bulbospinal neurons were identified by their conduction velocities below 6 m/s. These neurons, (which have been shown to be destroyed by 5,7-dihydroxytryptamine36), exist as two groups: a slower-conducting group with conduction velocities below 1.2 m/s, and a faster-conducting group with conduction velocities between 2 and 6 m/s. The neurons of the faster-conducting group were found to be similar to the non-serotonergic group in their firing, spike shapes and responses to sensory stimuli; while the units of the slower-conducting group were consistently found to fire between 0.03 and 6 Hz, to respond to sensory stimuli only with excitation, and to have distinctive spike shapes. Despite these differences, both groups of serotonergic units were found to be consistently inhibited by ACh, NE and 5-HT. In contrast to reports of serotonergic neurons in the midbrain, these units were not generally found to be inhibited by i.v. LSD. It is concluded that the serotonergic neurons of the medullary raphe are distinct both from the non-serotonergic neurons, and from serotonergic neurons in other parts of the brain.

Original languageEnglish (US)
Pages (from-to)93-103
Number of pages11
JournalBrain Research
Volume279
Issue number1-2
DOIs
StatePublished - Nov 21 1983
Externally publishedYes

Keywords

  • analgesic pathways
  • lysergic acid diethylamide
  • raphe nuclei
  • serotonergic neurons

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