Single-nucleotide polymorphism analysis by MALDI-TOF mass spectrometry

Timothy J. Griffin, Lloyd M. Smith

Research output: Contribution to journalReview article

179 Scopus citations

Abstract

Single-nucleotide polymorphisms (SNPs) have great potential for use in genetic-mapping studies, which locate and characterize genes that are important in human disease and biological function. For SNPs to realize their full potential in genetic analysis, thousands of different SNP loci must be screened in a rapid, accurate and cost-effective manner. Matrix-assisted laser desorption-ionization-time-of-flight (MALDI-TOF) mass spectrometry is a promising tool for the high-throughput screening of SNPs, with future prospects for use in genetic analysis.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalTrends in biotechnology
Volume18
Issue number2
DOIs
StatePublished - Feb 1 2000

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