Single-nucleotide polymorphism analysis by MALDI-TOF mass spectrometry

Timothy J. Griffin, Lloyd M. Smith

Research output: Contribution to journalReview articlepeer-review

193 Scopus citations


Single-nucleotide polymorphisms (SNPs) have great potential for use in genetic-mapping studies, which locate and characterize genes that are important in human disease and biological function. For SNPs to realize their full potential in genetic analysis, thousands of different SNP loci must be screened in a rapid, accurate and cost-effective manner. Matrix-assisted laser desorption-ionization-time-of-flight (MALDI-TOF) mass spectrometry is a promising tool for the high-throughput screening of SNPs, with future prospects for use in genetic analysis.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalTrends in biotechnology
Issue number2
StatePublished - Feb 1 2000

Bibliographical note

Funding Information:
We would like to acknowledge M. Scalf for his help in preparing this manuscript. T.J. Griffin was supported (in part) by a Proctor and Gamble predoctoral fellowship.


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