Single-fractionated stereotactic radiosurgery for intracranial meningioma in elderly patients: 25-year experience at a single institution

Hirotaka Hasegawa, Shunya Hanakita, Masahiro Shin, Tomoyuki Koga, Wataru Takahashi, Akihiro K. Nomoto, Madoka Sakuramachi, Nobuhito Saito

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


BACKGROUND: Stereotactic radiosurgery (SRS) has been accepted as a therapeutic option for intracranial meningiomas; however, the detailed data on outcomes in elderly patients remain unclear. OBJECTIVE: To delineate the efficacy of SRS for meningiomas in elderly patients. METHODS: The outcomes of 67 patients aged ≥ 65 yr who underwent SRS for benign intracranial meningioma (World Health Organization grade I) between 1990 and 2014 at our institution were retrospectively analyzed. The median age was 71 yr (range, 65-83 yr), and the mean and median follow-up were 62 and 52 mo (range, 7-195 mo), respectively. Tumor margins were irradiated with a median dose of 16 Gy, and the median tumor volume was 4.9 cm3 (range, 0.7-22.9 cm3). RESULTS: Actuarial local tumor control rates at 3, 5, and 10 yr after SRS were 92%, 86%, and 72%, respectively. Previous surgery and parasagittal/falcine location were statistically significant predictive factors for failed tumor control. Mild or moderate adverse events were noted in 9 patients. No severe adverse event was observed. A higher margin dose was significantly associated with adverse events by univariate analysis. CONCLUSION: SRS is one of the standard therapies for meningiomas in elderly patients, providing both favorable tumor control and a low risk of adverse events under minimum invasiveness.

Original languageEnglish (US)
Pages (from-to)341-350
Number of pages10
JournalOperative Neurosurgery
Issue number4
StatePublished - Apr 1 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 by the Congress of Neurological Surgeons.


  • Elderly population
  • Intracranial meningioma
  • Stereotactic radiosurgery


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