Single-Dose Cefmetazole Versus Multiple Dose Cefoxitin For Prophylaxis in Abdominal Surgery

Joseph T. Dipiro, Lynda S. Welage, Patricia E. Wing, Barry A. Levine, Johnny A. Stanfield, Harold V. Gaskill,, Deborah S. Scarfoni, Jerome J. Schentag, Talmadge A. Bowden, James S. Williams

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18 Scopus citations


One hundred and ninety-five patients undergoing abdominal surgical procedures completed a multicentre, randomized, open-label study comparing the safety and efficacy of cefmetazole and cefoxitin for the prevention of postoperative wound infection. Cefmetazole was administered iv in a single 2 g dose given within 90 min of the operation. Cefoxitin was administered in a single 2 g, similarly timed, preoperative dose and two additional doses given at 6 h intervals after surgery. For operations that exceeded 2-4 h duration an additional dose of each agent was administered. Patients undergoing colorectal operations received oral neomycin and erythromycin as bowel preparation. Colorectal operations were performed most frequently (49% of patients) followed by cholecystectomies (26%) and gastroduodenal procedures (21%). The operative site infection rate was 6-5% for cefmetazole and 7-7% for cefoxitin (P >0 05). Serious drug related adverse effects were not observed. This study demonstrates that administration of single-dose cefmetazole is as effective as a standard three dose regimen of cefoxitin for prophylaxis with abdominal operations.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
StatePublished - Jan 1 1989


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