Single chain folding of synthetic polymers by covalent and non-covalent interactions: Current status and future perspectives

Ozcan Altintas, Christopher Barner-Kowollik

Research output: Contribution to journalArticle

186 Scopus citations

Abstract

The present feature article highlights the preparation of polymeric nanoparticles and initial attempts towards mimicking the structure of natural biomacromolecules by single chain folding of well-defined linear polymers through covalent and non-covalent interactions. Initially, the discussion focuses on the synthesis and characterization of single chain self-folded structures by non-covalent interactions. The second part of the article summarizes the folding of single chain polymers by means of covalent interactions into nanoparticle systems. The current state of the art in the field of single chain folding indicates that covalent-bond-driven nanoparticle preparation is well advanced, while the first encouraging steps towards building reversible single chain folding systems by the use of mutually orthogonal hydrogen-bonding motifs have been made.

Original languageEnglish (US)
Pages (from-to)958-971
Number of pages14
JournalMacromolecular Rapid Communications
Volume33
Issue number11
DOIs
StatePublished - Jun 14 2012

Keywords

  • hydrogen driven bonding
  • intramolecular covalent bonds
  • modular ligation chemistry
  • natural biomacromolecule mimics
  • polymeric nanoparticles
  • single chain self-folding

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