Single center analysis of therapy and outcomes of hepatocellular carcinoma in Sub-Saharan Africa

Amir Sultan, Chimaobi M. Anugwom, Zerihun Wondifraw, Grace A. Braimoh, Abate Bane, Jose D. Debes

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Purpose: To evaluate the characteristics and response to therapy for HCC in sub-Saharan Africa. Patients and methods: We retrospectively evaluated demographic, clinical and outcome variables of HCC in a referral clinic in Ethiopia from 2016 to 2018. Survival assessment was performed using the Mann-Whitney test. Associations between categorical variables was assessed using Pearson Chi-square test. Results: We report 46 HCC cases with a median age of 54 years (IQR 45–62) and 50% female. Viral hepatitis was the most common underlying etiology, with 41% of subjects infected with hepatitis B virus (HBV) and 45% with hepatitis C. The median MELD was 12 (IQR 8–17), we found no association between survival and a MELD score </> 15, regardless of underlying disease (pr=0.61, p>0.05). 31% of individuals underwent supportive treatment with a median survival of 27 days (IQR 19–181), 18% used Sorafenib (median survival of 94 days, IQR 24–121), and trans-arterial chemoembolization (TACE) was utilized in 16% (median survival of 352 days, IQR 30–436). HBV cases were diagnosed younger (31% before the age of 40) and those on Tenofovir had a longer median survival than those off Tenofovir (121 vs 34 days). Conclusion: Our study found that antiviral treatment of HBV infection was associated with longer survival in HCC. Furthermore, Sorafenib seemed beneficial in patients that used this modality and NLR was a good prognostic factor.

Original languageEnglish (US)
Pages (from-to)1007-1011
Number of pages5
JournalExpert Review of Gastroenterology and Hepatology
Volume14
Issue number10
DOIs
StatePublished - Oct 2 2020

Bibliographical note

Funding Information:
This paper was funded in part by the University of Minnesota Center for Global Health and Social Responsibility Global Health Seed Award and NIH-NCI R21 CA215883-01A1.

Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Ethiopia
  • Hepatocellular carcinoma
  • Sorafenib
  • outcomes

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