Single-cell sequencing in ovarian cancer: A new frontier in precision medicine

Boris Winterhoff, Shobhana Talukdar, Zenas Chang, Jinhua Wang, Timothy K. Starr

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Purpose of reviewThis article discusses the advances, applications and challenges of using single-cell RNA sequencing data in guiding treatment decisions for ovarian cancer.Recent findingsGenetic heterogeneity is a hallmark of ovarian cancer biology and underlies treatment resistance. Defining the different cell types present within a single ovarian cancer is difficult, but could ultimately lead to improvements in diagnosis and treatment. Next-generation sequencing technologies have rapidly increased our understanding of the molecular landscape of epithelial ovarian cancers, but the majority of these studies are conducted on bulk samples, resulting in data that represents an 'average' of all cells present. Single-cell sequencing provides a means to characterize heterogeneity with a tumor tissue in ovarian cancer patients and opens up opportunity to determine key molecular properties that influence clinical outcomes, including prognosis and treatment response.SummarySingle-cell sequencing provides a powerful tool in improving our understanding of tumor cell heterogeneity for the purpose of informing personalized cancer treatment.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalCurrent Opinion in Obstetrics and Gynecology
Volume31
Issue number1
DOIs
StatePublished - Feb 1 2019

Bibliographical note

Funding Information:
B.W. currently receives grant funding from the Ovarian Cancer Research Foundation as well as the University of Minnesota Genomics Center, and the University of Minnesota Grand Challenges program for this current work. T.K.S and J.W. receive funding from the University of Minnesota Genomics Center, and the University of Minnesota Grand Challenges program for this current work. Furthermore, institutional UL1TR000114 awarded by National Center for Advancing Translational Sciences and CA77598 awarded by National Cancer Institute are supporting this current work.

Publisher Copyright:
© 2019 Lippincott Williams and Wilkins. All rights reserved.

Keywords

  • ovarian cancer
  • precision medicine
  • single-cell RNA sequencing

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