Simvastatin, a competitive inhibitor of HMG‐CoA reductase, lowers cholesterol saturation index of gallbladder bile

William C. Duane, Donald B. Hunninghake, Martin L. Freeman, Pete A. Pooler, Linda A. Schlasner, Roger L. Gebhard

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

We tested the possibility that simvastatin, a competitive inhibitor of HMG‐CoA reductase related to mevinolin, might alter cholesterol saturation of gallbladder bile. Ten patients with Type IIa or IIb hypercholesterolemia underwent bile sampling before, and again after, treatment with 20 or 40 mg per day simvastatin for 7 to 13 weeks. Mean cholesterol saturation index of gallbladder bile fell from 1.01 to 0.77 during simvastatin treatment (p < 0.01). This finding strongly suggests that treatment with HMG‐CoA reductase inhibitors will not predispose to development of cholesterol gallstones. Indeed, it raises the possibility that such inhibitors might have a future role to play in treatment of gallstones.

Original languageEnglish (US)
Pages (from-to)1147-1150
Number of pages4
JournalHepatology
Volume8
Issue number5
DOIs
StatePublished - Jan 1 1988

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