Simultaneous multislice imaging for native myocardial T1 mapping

Improved spatial coverage in a single breath-hold

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7 Citations (Scopus)

Abstract

Purpose: To develop a saturation recovery myocardial T1 mapping method for the simultaneous multislice acquisition of three slices. Methods: Saturation pulse-prepared heart rate independent inversion recovery (SAPPHIRE) T1 mapping was implemented with simultaneous multislice imaging using FLASH readouts for faster coverage of the myocardium. Controlled aliasing in parallel imaging (CAIPI) was used to achieve minimal noise amplification in three slices. Multiband reconstruction was performed using three linear reconstruction methods: Slice- and in-plane GRAPPA, CG-SENSE, and Tikhonov-regularized CG-SENSE. Accuracy, spatial variability, and interslice leakage were compared with single-band T1 mapping in a phantom and in six healthy subjects. Results: Multiband phantom T1 times showed good agreement with single-band T1 mapping for all three reconstruction methods (normalized root mean square error <1.0%). The increase in spatial variability compared with single-band imaging was lowest for GRAPPA (1.29-fold), with higher penalties for Tikhonov-regularized CG-SENSE (1.47-fold) and CG-SENSE (1.52-fold). In vivo multiband T1 times showed no significant difference compared with single-band (T1 time ± intersegmental variability: single-band, 1580 ± 119 ms; GRAPPA, 1572 ± 145 ms; CG-SENSE, 1579 ± 159 ms; Tikhonov, 1586 ± 150 ms [analysis of variance; P = 0.86]). Interslice leakage was smallest for GRAPPA (5.4%) and higher for CG-SENSE (6.2%) and Tikhonov-regularized CG-SENSE (7.9%). Conclusion: Multiband accelerated myocardial T1 mapping demonstrated the potential for single–breath-hold T1 quantification in 16 American Heart Association segments over three slices. A 1.2- to 1.4-fold higher in vivo spatial variability was observed, where GRAPPA-based reconstruction showed the highest homogeneity and the least interslice leakage. Magn Reson Med 78:462–471, 2017.

Original languageEnglish (US)
Pages (from-to)462-471
Number of pages10
JournalMagnetic resonance in medicine
Volume78
Issue number2
DOIs
StatePublished - Aug 1 2017

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Noise
Myocardium
Analysis of Variance
Healthy Volunteers
Heart Rate

Keywords

  • SAPPHIRE
  • multiband
  • myocardial T mapping
  • saturation recovery
  • simultaneous multislice imaging

Cite this

@article{b9fa24e6928b45a68f4cc793d738eb73,
title = "Simultaneous multislice imaging for native myocardial T1 mapping: Improved spatial coverage in a single breath-hold",
abstract = "Purpose: To develop a saturation recovery myocardial T1 mapping method for the simultaneous multislice acquisition of three slices. Methods: Saturation pulse-prepared heart rate independent inversion recovery (SAPPHIRE) T1 mapping was implemented with simultaneous multislice imaging using FLASH readouts for faster coverage of the myocardium. Controlled aliasing in parallel imaging (CAIPI) was used to achieve minimal noise amplification in three slices. Multiband reconstruction was performed using three linear reconstruction methods: Slice- and in-plane GRAPPA, CG-SENSE, and Tikhonov-regularized CG-SENSE. Accuracy, spatial variability, and interslice leakage were compared with single-band T1 mapping in a phantom and in six healthy subjects. Results: Multiband phantom T1 times showed good agreement with single-band T1 mapping for all three reconstruction methods (normalized root mean square error <1.0{\%}). The increase in spatial variability compared with single-band imaging was lowest for GRAPPA (1.29-fold), with higher penalties for Tikhonov-regularized CG-SENSE (1.47-fold) and CG-SENSE (1.52-fold). In vivo multiband T1 times showed no significant difference compared with single-band (T1 time ± intersegmental variability: single-band, 1580 ± 119 ms; GRAPPA, 1572 ± 145 ms; CG-SENSE, 1579 ± 159 ms; Tikhonov, 1586 ± 150 ms [analysis of variance; P = 0.86]). Interslice leakage was smallest for GRAPPA (5.4{\%}) and higher for CG-SENSE (6.2{\%}) and Tikhonov-regularized CG-SENSE (7.9{\%}). Conclusion: Multiband accelerated myocardial T1 mapping demonstrated the potential for single–breath-hold T1 quantification in 16 American Heart Association segments over three slices. A 1.2- to 1.4-fold higher in vivo spatial variability was observed, where GRAPPA-based reconstruction showed the highest homogeneity and the least interslice leakage. Magn Reson Med 78:462–471, 2017.",
keywords = "SAPPHIRE, multiband, myocardial T mapping, saturation recovery, simultaneous multislice imaging",
author = "Sebastian Weing{\"a}rtner and Steen Moeller and Sebastian Schmitter and Auerbach, {Edward J} and Peter Kellman and Shenoy, {Chetan N} and Mehmet Akcakaya",
year = "2017",
month = "8",
day = "1",
doi = "10.1002/mrm.26770",
language = "English (US)",
volume = "78",
pages = "462--471",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Simultaneous multislice imaging for native myocardial T1 mapping

T2 - Improved spatial coverage in a single breath-hold

AU - Weingärtner, Sebastian

AU - Moeller, Steen

AU - Schmitter, Sebastian

AU - Auerbach, Edward J

AU - Kellman, Peter

AU - Shenoy, Chetan N

AU - Akcakaya, Mehmet

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Purpose: To develop a saturation recovery myocardial T1 mapping method for the simultaneous multislice acquisition of three slices. Methods: Saturation pulse-prepared heart rate independent inversion recovery (SAPPHIRE) T1 mapping was implemented with simultaneous multislice imaging using FLASH readouts for faster coverage of the myocardium. Controlled aliasing in parallel imaging (CAIPI) was used to achieve minimal noise amplification in three slices. Multiband reconstruction was performed using three linear reconstruction methods: Slice- and in-plane GRAPPA, CG-SENSE, and Tikhonov-regularized CG-SENSE. Accuracy, spatial variability, and interslice leakage were compared with single-band T1 mapping in a phantom and in six healthy subjects. Results: Multiband phantom T1 times showed good agreement with single-band T1 mapping for all three reconstruction methods (normalized root mean square error <1.0%). The increase in spatial variability compared with single-band imaging was lowest for GRAPPA (1.29-fold), with higher penalties for Tikhonov-regularized CG-SENSE (1.47-fold) and CG-SENSE (1.52-fold). In vivo multiband T1 times showed no significant difference compared with single-band (T1 time ± intersegmental variability: single-band, 1580 ± 119 ms; GRAPPA, 1572 ± 145 ms; CG-SENSE, 1579 ± 159 ms; Tikhonov, 1586 ± 150 ms [analysis of variance; P = 0.86]). Interslice leakage was smallest for GRAPPA (5.4%) and higher for CG-SENSE (6.2%) and Tikhonov-regularized CG-SENSE (7.9%). Conclusion: Multiband accelerated myocardial T1 mapping demonstrated the potential for single–breath-hold T1 quantification in 16 American Heart Association segments over three slices. A 1.2- to 1.4-fold higher in vivo spatial variability was observed, where GRAPPA-based reconstruction showed the highest homogeneity and the least interslice leakage. Magn Reson Med 78:462–471, 2017.

AB - Purpose: To develop a saturation recovery myocardial T1 mapping method for the simultaneous multislice acquisition of three slices. Methods: Saturation pulse-prepared heart rate independent inversion recovery (SAPPHIRE) T1 mapping was implemented with simultaneous multislice imaging using FLASH readouts for faster coverage of the myocardium. Controlled aliasing in parallel imaging (CAIPI) was used to achieve minimal noise amplification in three slices. Multiband reconstruction was performed using three linear reconstruction methods: Slice- and in-plane GRAPPA, CG-SENSE, and Tikhonov-regularized CG-SENSE. Accuracy, spatial variability, and interslice leakage were compared with single-band T1 mapping in a phantom and in six healthy subjects. Results: Multiband phantom T1 times showed good agreement with single-band T1 mapping for all three reconstruction methods (normalized root mean square error <1.0%). The increase in spatial variability compared with single-band imaging was lowest for GRAPPA (1.29-fold), with higher penalties for Tikhonov-regularized CG-SENSE (1.47-fold) and CG-SENSE (1.52-fold). In vivo multiband T1 times showed no significant difference compared with single-band (T1 time ± intersegmental variability: single-band, 1580 ± 119 ms; GRAPPA, 1572 ± 145 ms; CG-SENSE, 1579 ± 159 ms; Tikhonov, 1586 ± 150 ms [analysis of variance; P = 0.86]). Interslice leakage was smallest for GRAPPA (5.4%) and higher for CG-SENSE (6.2%) and Tikhonov-regularized CG-SENSE (7.9%). Conclusion: Multiband accelerated myocardial T1 mapping demonstrated the potential for single–breath-hold T1 quantification in 16 American Heart Association segments over three slices. A 1.2- to 1.4-fold higher in vivo spatial variability was observed, where GRAPPA-based reconstruction showed the highest homogeneity and the least interslice leakage. Magn Reson Med 78:462–471, 2017.

KW - SAPPHIRE

KW - multiband

KW - myocardial T mapping

KW - saturation recovery

KW - simultaneous multislice imaging

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U2 - 10.1002/mrm.26770

DO - 10.1002/mrm.26770

M3 - Article

VL - 78

SP - 462

EP - 471

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

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