Simultaneous multi-slice Turbo-FLASH imaging with CAIPIRINHA for whole brain distortion-free pseudo-continuous arterial spin labeling at 3 and 7T

Yi Wang; Steen Moeller; Xiufeng Li; An T. Vu; Kate Krasileva; Kamil Ugurbil; Essa Yacoub; Danny J.J. Wang

doi:10.1016/j.neuroimage.2015.03.060

Simultaneous multi-slice Turbo-FLASH imaging with CAIPIRINHA for whole brain distortion-free pseudo-continuous arterial spin labeling at 3 and 7T

Yi Wang, Steen Moeller, Xiufeng Li, An T. Vu, Kate Krasileva, Kamil Ugurbil, Essa Yacoub, Danny J.J. Wang

Radiology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Simultaneous multi-slice (SMS) or multiband (MB) imaging has recently been attempted for arterial spin labeled (ASL) perfusion MRI in conjunction with echo-planar imaging (EPI) readout. It was found that SMS-EPI can reduce the T₁ relaxation effect of the label and improve image coverage and resolution with little penalty in signal-to-noise ratio (SNR). However, EPI still suffers from geometric distortion and signal dropout from field inhomogeneity effects especially at high and ultrahigh magnetic fields. Here we present a novel scheme for achieving high fidelity distortion-free quantitative perfusion imaging by combining pseudo-continuous ASL (pCASL) with SMS Turbo-FLASH (TFL) readout at both 3 and 7T. Bloch equation simulation was performed to characterize and optimize the TFL-based pCASL perfusion signal. Two MB factors (3 and 5) were implemented in SMS-TFL pCASL and compared with standard 2D TFL and EPI pCASL sequences. The temporal SNR of SMS-TFL pCASL relative to that of standard TFL pCASL was 0.76±0.10 and 0.74±0.11 at 7T and 0.70±0.05 and 0.65±0.05 at 3T for MB factor of 3 and 5, respectively. By implementing background suppression in conjunction with SMS-TFL at 3T, the relative temporal SNR improved to 0.84±0.09 and 0.79±0.10 for MB factor of 3 and 5, respectively. Compared to EPI pCASL, significantly increased temporal SNR (p<0.001) and improved visualization of orbitofrontal cortex were achieved using SMS-TFL pCASL. By combining SMS acceleration with TFL pCASL, we demonstrated the feasibility for whole brain distortion-free quantitative mapping of cerebral blood flow at high and ultrahigh magnetic fields.

Original language	English (US)
Pages (from-to)	279-288
Number of pages	10
Journal	NeuroImage
Volume	113
DOIs	https://doi.org/10.1016/j.neuroimage.2015.03.060
State	Published - Jun 1 2015

Bibliographical note

Funding Information:
This research was supported by the National Institute of Health (NIH) Grants R01-MH080892 , R01-NS081077 , and R01-EB014922 , the NIH Human Connectome Project ( NIH U54MH091657 ), the Biomedical Technology Resource Centers (BTRC) National Center for Research Resources (NCRR; P41 RR08079 ), the National Institute of Biomedical Imaging and Bioengineering (NIBIB; P41 EB015894 ) and the Siemens Healthcare USA, Inc. In addition, the authors would like to acknowledge Robert Smith for the helpful discussion on the manuscript and Kay Jann for the statistical analysis.

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

Arterial spin labeling (ASL)
Cerebral blood flow (CBF)
Multiband (MB)
Simultaneous multi-slice (SMS)
Turbo-FLASH (TFL)

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@article{91851d0b703344528f809d6069599bfe,

title = "Simultaneous multi-slice Turbo-FLASH imaging with CAIPIRINHA for whole brain distortion-free pseudo-continuous arterial spin labeling at 3 and 7T",

abstract = "Simultaneous multi-slice (SMS) or multiband (MB) imaging has recently been attempted for arterial spin labeled (ASL) perfusion MRI in conjunction with echo-planar imaging (EPI) readout. It was found that SMS-EPI can reduce the T1 relaxation effect of the label and improve image coverage and resolution with little penalty in signal-to-noise ratio (SNR). However, EPI still suffers from geometric distortion and signal dropout from field inhomogeneity effects especially at high and ultrahigh magnetic fields. Here we present a novel scheme for achieving high fidelity distortion-free quantitative perfusion imaging by combining pseudo-continuous ASL (pCASL) with SMS Turbo-FLASH (TFL) readout at both 3 and 7T. Bloch equation simulation was performed to characterize and optimize the TFL-based pCASL perfusion signal. Two MB factors (3 and 5) were implemented in SMS-TFL pCASL and compared with standard 2D TFL and EPI pCASL sequences. The temporal SNR of SMS-TFL pCASL relative to that of standard TFL pCASL was 0.76±0.10 and 0.74±0.11 at 7T and 0.70±0.05 and 0.65±0.05 at 3T for MB factor of 3 and 5, respectively. By implementing background suppression in conjunction with SMS-TFL at 3T, the relative temporal SNR improved to 0.84±0.09 and 0.79±0.10 for MB factor of 3 and 5, respectively. Compared to EPI pCASL, significantly increased temporal SNR (p<0.001) and improved visualization of orbitofrontal cortex were achieved using SMS-TFL pCASL. By combining SMS acceleration with TFL pCASL, we demonstrated the feasibility for whole brain distortion-free quantitative mapping of cerebral blood flow at high and ultrahigh magnetic fields.",

keywords = "Arterial spin labeling (ASL), Cerebral blood flow (CBF), Multiband (MB), Simultaneous multi-slice (SMS), Turbo-FLASH (TFL)",

author = "Yi Wang and Steen Moeller and Xiufeng Li and Vu, {An T.} and Kate Krasileva and Kamil Ugurbil and Essa Yacoub and Wang, {Danny J.J.}",

note = "Funding Information: This research was supported by the National Institute of Health (NIH) Grants R01-MH080892 , R01-NS081077 , and R01-EB014922 , the NIH Human Connectome Project ( NIH U54MH091657 ), the Biomedical Technology Resource Centers (BTRC) National Center for Research Resources (NCRR; P41 RR08079 ), the National Institute of Biomedical Imaging and Bioengineering (NIBIB; P41 EB015894 ) and the Siemens Healthcare USA, Inc. In addition, the authors would like to acknowledge Robert Smith for the helpful discussion on the manuscript and Kay Jann for the statistical analysis. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = jun,

day = "1",

doi = "10.1016/j.neuroimage.2015.03.060",

language = "English (US)",

volume = "113",

pages = "279--288",

journal = "NeuroImage",

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TY - JOUR

T1 - Simultaneous multi-slice Turbo-FLASH imaging with CAIPIRINHA for whole brain distortion-free pseudo-continuous arterial spin labeling at 3 and 7T

AU - Wang, Yi

AU - Moeller, Steen

AU - Li, Xiufeng

AU - Vu, An T.

AU - Krasileva, Kate

AU - Ugurbil, Kamil

AU - Yacoub, Essa

AU - Wang, Danny J.J.

N1 - Funding Information: This research was supported by the National Institute of Health (NIH) Grants R01-MH080892 , R01-NS081077 , and R01-EB014922 , the NIH Human Connectome Project ( NIH U54MH091657 ), the Biomedical Technology Resource Centers (BTRC) National Center for Research Resources (NCRR; P41 RR08079 ), the National Institute of Biomedical Imaging and Bioengineering (NIBIB; P41 EB015894 ) and the Siemens Healthcare USA, Inc. In addition, the authors would like to acknowledge Robert Smith for the helpful discussion on the manuscript and Kay Jann for the statistical analysis. Publisher Copyright: © 2015 Elsevier Inc.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Simultaneous multi-slice (SMS) or multiband (MB) imaging has recently been attempted for arterial spin labeled (ASL) perfusion MRI in conjunction with echo-planar imaging (EPI) readout. It was found that SMS-EPI can reduce the T1 relaxation effect of the label and improve image coverage and resolution with little penalty in signal-to-noise ratio (SNR). However, EPI still suffers from geometric distortion and signal dropout from field inhomogeneity effects especially at high and ultrahigh magnetic fields. Here we present a novel scheme for achieving high fidelity distortion-free quantitative perfusion imaging by combining pseudo-continuous ASL (pCASL) with SMS Turbo-FLASH (TFL) readout at both 3 and 7T. Bloch equation simulation was performed to characterize and optimize the TFL-based pCASL perfusion signal. Two MB factors (3 and 5) were implemented in SMS-TFL pCASL and compared with standard 2D TFL and EPI pCASL sequences. The temporal SNR of SMS-TFL pCASL relative to that of standard TFL pCASL was 0.76±0.10 and 0.74±0.11 at 7T and 0.70±0.05 and 0.65±0.05 at 3T for MB factor of 3 and 5, respectively. By implementing background suppression in conjunction with SMS-TFL at 3T, the relative temporal SNR improved to 0.84±0.09 and 0.79±0.10 for MB factor of 3 and 5, respectively. Compared to EPI pCASL, significantly increased temporal SNR (p<0.001) and improved visualization of orbitofrontal cortex were achieved using SMS-TFL pCASL. By combining SMS acceleration with TFL pCASL, we demonstrated the feasibility for whole brain distortion-free quantitative mapping of cerebral blood flow at high and ultrahigh magnetic fields.

AB - Simultaneous multi-slice (SMS) or multiband (MB) imaging has recently been attempted for arterial spin labeled (ASL) perfusion MRI in conjunction with echo-planar imaging (EPI) readout. It was found that SMS-EPI can reduce the T1 relaxation effect of the label and improve image coverage and resolution with little penalty in signal-to-noise ratio (SNR). However, EPI still suffers from geometric distortion and signal dropout from field inhomogeneity effects especially at high and ultrahigh magnetic fields. Here we present a novel scheme for achieving high fidelity distortion-free quantitative perfusion imaging by combining pseudo-continuous ASL (pCASL) with SMS Turbo-FLASH (TFL) readout at both 3 and 7T. Bloch equation simulation was performed to characterize and optimize the TFL-based pCASL perfusion signal. Two MB factors (3 and 5) were implemented in SMS-TFL pCASL and compared with standard 2D TFL and EPI pCASL sequences. The temporal SNR of SMS-TFL pCASL relative to that of standard TFL pCASL was 0.76±0.10 and 0.74±0.11 at 7T and 0.70±0.05 and 0.65±0.05 at 3T for MB factor of 3 and 5, respectively. By implementing background suppression in conjunction with SMS-TFL at 3T, the relative temporal SNR improved to 0.84±0.09 and 0.79±0.10 for MB factor of 3 and 5, respectively. Compared to EPI pCASL, significantly increased temporal SNR (p<0.001) and improved visualization of orbitofrontal cortex were achieved using SMS-TFL pCASL. By combining SMS acceleration with TFL pCASL, we demonstrated the feasibility for whole brain distortion-free quantitative mapping of cerebral blood flow at high and ultrahigh magnetic fields.

KW - Arterial spin labeling (ASL)

KW - Cerebral blood flow (CBF)

KW - Multiband (MB)

KW - Simultaneous multi-slice (SMS)

KW - Turbo-FLASH (TFL)

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DO - 10.1016/j.neuroimage.2015.03.060

M3 - Article

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SN - 1053-8119

VL - 113

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EP - 288

JO - NeuroImage

JF - NeuroImage

ER -

Simultaneous multi-slice Turbo-FLASH imaging with CAIPIRINHA for whole brain distortion-free pseudo-continuous arterial spin labeling at 3 and 7T

Abstract

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Keywords

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