Simultaneous in situ detection of viral RNA and antigens

M. Brahic, A. T. Haase, E. Cash

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


We have combined in situ hybridization and immunocytochemistry to detect RNA and proteins in the same cell. We envision a wide range of applications for this method, and, as one example, we show that viral genomes and capsid antigens can be detected simultaneously in paraffin sections of the central nervous system of mice infected with Theiler's virus, the causative agent of a slow demyelinating disease.

Original languageEnglish (US)
Pages (from-to)5445-5448
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number17 I
StatePublished - 1984


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